- 8-Aminooctanoic acid
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- $5.00
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2026-05-28
- CAS:1002-57-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10000kg
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| | 8-Aminooctanoic acid Basic information |
| Product Name: | 8-Aminooctanoic acid | | Synonyms: | H-AOC(8)-OH;8-AMINOOCTANOIC ACID;w-Aminocaprylic acid;H-8-AMINOCAPRYLIC ACID;H-8-AMINOOCTANOIC ACID;GAMMA-AMINOCAPRYLIC ACID;NH2-(CH2)7-COOH;OMEGA-AMINOCAPRYLIC ACID | | CAS: | 1002-57-9 | | MF: | C8H17NO2 | | MW: | 159.23 | | EINECS: | 213-687-9 | | Product Categories: | Amino Acids | | Mol File: | 1002-57-9.mol |  |
| | 8-Aminooctanoic acid Chemical Properties |
| Melting point | 194 °C (dec.) (lit.) | | Boiling point | 286.0±23.0 °C(Predicted) | | density | 1.0500 (estimate) | | refractive index | 1.4630 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Methanol (Very Slightly), Water (Slightly) | | pka | 4.76±0.10(Predicted) | | form | Crystalline Powder | | color | White to slightly beige | | Water Solubility | Soluble in water. | | BRN | 1756493 | | Major Application | peptide synthesis | | InChI | InChI=1S/C8H17NO2/c9-7-5-3-1-2-4-6-8(10)11/h1-7,9H2,(H,10,11) | | InChIKey | UQXNEWQGGVUVQA-UHFFFAOYSA-N | | SMILES | C(O)(=O)CCCCCCCN | | CAS DataBase Reference | 1002-57-9(CAS DataBase Reference) | | NIST Chemistry Reference | 8-Aminocaprylic acid(1002-57-9) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25-37/39-26 | | WGK Germany | 3 | | HS Code | 29224985 | | Storage Class | 11 - Combustible Solids |
| | 8-Aminooctanoic acid Usage And Synthesis |
| Chemical Properties | WHITE TO SLIGHTLY BEIGE CRYSTALLINE POWDER | | Uses | 8-Aminooctanoic acid is involved in the preparation of lactams using enzyme catalyzed aminolysis. | | Definition | ChEBI: 8-aminooctanoic acid is an omega-amino fatty acid that is octanoic acid which carries an amino group at position 8. It has a role as a human metabolite. It is a medium-chain fatty acid and an omega-amino fatty acid. | | Reactivity Profile | Other lactams such as butyrolactam, d-valerolactam, and dimer and trimer lactams can be formed from enzymatic reactions of 4-aminobutanoic acid, 5-aminovaleric acid, and 8-aminooctanoic acid using N435 as the catalyst. For reactions using 8-aminooctanoic acid as the substrate, N435 did not catalyze the formation of caprylolactam. Instead, the corresponding dimer and trimer lactams were formed. The formation of macrocyclic bislactams from reactions between diesters and diamines using porcine pancreatic lipase as the catalyst was previously reported. However, in the enzymatic reaction of 8-aminooctanoic acid using N435, different macrocyclic dimer and trimer lactams were formed in a ratio of 3:2. The ratio was calculated from the mass spectrometric peak intensities of the product[2].
| | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | In a 1 l flask with paddle stirrer, internal thermometer and reflux condenser, 142.6 g (1 mol) of 2-azacyclononanone and 110 g (1 mol) of about 36 wt.-% sodium hydroxide solution are boiled under reflux for 4 hours. The solution is subsequently cooled to about 80 °C and mixed with Lewatit SP-112. After one hour, the acidic ion exchanger is filtered. 500 g of 2-Propanol is added dropwise to the mixture at 80 °C, and the homogeneous solution is slowly cooled to -5 °C. The precipitated solid is filtered and washed with 50 g of 2-propanol. After drying at 85 °C and 20 mbar, 8-Aminooctanoic acid is obtained as a fine colorless powder. A colorless powder. Yield: 127 g (80%). Melting point: 191-193 °C (Lit.: 194 °C).
 | | structure and hydrogen bonding |  | | References |
[1] A J Dobson, R E Gerkin. “8-Aminocaprylic acid.” Acta crystallographica. Section C, Crystal structure communications 54 ( Pt 7) (1998): 969–72.
[2] E. Stavila, K. Loos. “Synthesis of lactams using enzyme-catalyzed aminolysis.” Tetrahedron Letters 54 5 (2013): Pages 370-372.
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| | 8-Aminooctanoic acid Preparation Products And Raw materials |
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