- Tolperisone
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- $15.00 / 1KG
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2021-08-12
- CAS:728-88-1
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | Tolperisone Basic information |
| Product Name: | Tolperisone | | Synonyms: | AKOS 91983;1-piperidino-2-methyl-3-(p-tolyl)-3-propanone;2,4’-dimethyl-3-piperidino-propiophenon;2-methyl-3-piperidino-1-p-tolylpropan-1-one;mydeton;TOLPERISONE;α,4'-Dimethyl-β-piperidinopropiophenone;2-methyl-1-(4-methylphenyl)-3-piperidin-1-yl-propan-1-one | | CAS: | 728-88-1 | | MF: | C16H23NO | | MW: | 245.36 | | EINECS: | 211-976-4 | | Product Categories: | | | Mol File: | 728-88-1.mol |  |
| | Tolperisone Chemical Properties |
| Melting point | 176.5°C | | Boiling point | 388.33°C (rough estimate) | | density | 0.9672 (rough estimate) | | refractive index | 1.5500 (estimate) | | pka | 8.47±0.10(Predicted) | | CAS DataBase Reference | 728-88-1(CAS DataBase Reference) |
| | Tolperisone Usage And Synthesis |
| Originator | Tolperisone hydrochloride,Shanghai Abochem
Chemical Co. | | Definition | ChEBI: 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone is an aromatic ketone. | | Manufacturing Process | To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added
an excess of thionyl chloride and the reaction mixture refluxed until
completed. It was then taken to dryness under reduced pressure and the
residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate.
An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine
hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered
palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone
was purified by distilling the base (boiling point 106-107°C/1 mm) and
reconverting to the hydrochloride, melting point 216-217°C. | | Brand name | Tolperisone Hydrochloride
is JAN. | | Therapeutic Function | Muscle relaxant, Vasodilator | | Synthesis Reference(s) | Chemical and Pharmaceutical Bulletin, 42, p. 1676, 1994 DOI: 10.1248/cpb.42.1676 |
| | Tolperisone Preparation Products And Raw materials |
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