- Citric Acid Monohydrate
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- $5.00 / 1000kg
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2022-04-01
- CAS:5949-29-1
- Min. Order: 1000kg
- Purity: 99%HPLC,USP Standard
- Supply Ability: 80000kgs
- Citric acid monohydrate
-
- $2200.00 / 1ton
-
2022-03-17
- CAS:5949-29-1
- Min. Order: 1ton
- Purity: 99
- Supply Ability: 1000ton/month
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| | Citric acid monohydrate Basic information |
| Product Name: | Citric acid monohydrate | | Synonyms: | 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, monohydrate;1,2,3-Propanetricarboxylicacid,2-hydroxy-,monohydrate;2,3-propanetricarboxylicacid,2-hydroxy-monohydrate;citric;Citric acid hydrate;Citricacidhydrate;Citronensαure-hydrat;Citric acid monohydrate, 99.5+% | | CAS: | 5949-29-1 | | MF: | C6H10O8 | | MW: | 210.1388 | | EINECS: | 200-662-2 | | Product Categories: | BioXtra Buffers;Biological Buffers;Buffers A to Z;Building Blocks;C6;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Nutrition Research;Organic Building Blocks;Other Biochemical;Phytochemicals by Chemical Classification;ACS Grade;Essential Chemicals;C-D, Puriss p.a. ACS;Puriss p.a. ACS;Buffers A to ZCarbonyl Compounds;Other BiochemicalBiological Buffers;Biochemicals Found in Plants;C6Nutrition Research;Carboxylic Acids;SigmaUltra Buffers;ACS GradeCarbonyl Compounds;Essential Chemicals;Other Biochemical;Inorganic Salts;Research Essentials;Solutions and Reagents;Citric Acid Monohydrate is mainly used as acidulating, flavoring and preservative in foods and beverages;Food additive and acidulant;Analytical Reagents;Analytical Reagents for General Use;Puriss;Buffers A to ZEssential Chemicals;USP/MultiCompendial Grade Buffers;USPBiological Buffers;Biological Buffers;Routine Reagents;Buffers A to ZNutrition Research;Reagent GradeMetabolic Pathways;Metabolites and Cofactors on the Metabolic Pathways Chart;Other BiochemicalEssential Chemicals;TCA;5949-29-1 | | Mol File: | 5949-29-1.mol |  |
| | Citric acid monohydrate Chemical Properties |
| Melting point | -94 °C(lit.) | | Boiling point | 56 °C760 mm Hg(lit.) | | density | 0.791 g/mL at 25 °C(lit.) | | vapor density | 2 (vs air) | | vapor pressure | 184 mm Hg ( 20 °C) | | refractive index | n20/D 1.359(lit.) | | Fp | 1 °F | | storage temp. | no restrictions. | | solubility | Citric Acid Monohydrate is very soluble in water, freely soluble in ethanol and sparingly soluble in ether. | | pka | 3.138, 4.76, 6.401 | | form | Solid | | color | White | | Specific Gravity | 0.810 (20/4℃) | | PH | 1.85 (50g/l, H2O, 25℃) | | Water Solubility | 1630 g/L (20 oC) ;H2O: soluble 54% (w/w) at 10°C (Citric acid in water) | | Sensitive | Hygroscopic | | Merck | 14,2326 | | BRN | 4018641 | | Stability: | Stable. Incompatible with oxidizing agents, bases, reducing agents, nitrates. | | InChIKey | YASYEJJMZJALEJ-UHFFFAOYSA-N | | CAS DataBase Reference | 5949-29-1(CAS DataBase Reference) | | NIST Chemistry Reference | Citric acid monohydrate(5949-29-1) | | EPA Substance Registry System | 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) (5949-29-1) |
| | Citric acid monohydrate Usage And Synthesis |
| Chemical Properties | Citric acid monohydrate occurs as colorless or translucent crystals, or as a white crystalline, efflorescent powder. It is odorless and has a strong acidic taste. The crystal structure is orthorhombic. monohydrate crystals lose water of crystallization in dry air or when heated to about 40 to 50 °C. Citric acid monohydrate softens at 75 °C and melts at approximately 100 °C.
Citric acid monohydrate is a natural preservative and is used to add an acidic, or sour, taste to foods and soft drinks.
Citric acid monohydrate acts as a preservative and antioxidant. It is also used as an acidulant, flavoring agent and antistaling agent in fruit drinks, candy, cookies, biscuits, canned fruits, jams, and jellies. It differs from other forms of citric acid by having a moisture percentage ranging from 7.5-9.0.
| | Uses | Citric Acid Monohydrate is used as an Acidulate, Food additive, Pharmaceutical application and as a synergist in antioxidant mixtures.
Citric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients and is used as a preservative. It is also used as an acidulant to control pH and acts as an anticoagulant by chelating calcium in blood. | | Uses | Citric acid monohydrate has been used:
- as carbon source of carbon nanodot synthesis
- in the preparation of citric acid monohydrate solution/buffer of pH-6.0 for tissue sample preparation
- to treat various samples in citric acid solubilisation technique
| | Uses | Citric acid monohydrate is used in the preparation of citrate buffer in platelets for intravital microscopy. It acts as a pH-control agent in foods, beverages and pharmaceuticals applications. It acts as an iron chelator. In animals, it improves the utilization of nutritional calcium. It is a useful buffer component for antigen and epitope unmasking. It is also used as an acidifier, a flavoring agent and a chelating agent. | | Production Methods | At present, the production method of citric acid monohydrate crystal in industry includes first separating the citric acid fermentation liquid from solid-liquid to obtain citric acid clear liquid, Citric acid clear night through calcium salt method The purified solution obtained by (hydrogen calcium method), acidolysis and decolorization is heated, concentrated and crystallized to produce anhydrous citric acid. The mother liquor separated from anhydrous citric acid crystal slurry is put into the crystallization cylinder after being filtered by plate and frame, and the citric acid concentrated solution reaches the supersaturated state through cooling to precipitate the crystal. When the temperature is reduced to about 13 ℃, centrifugal separation is started, and the wet crystal enters the dryer for drying dry. After the mother liquor is filtered, decolorized and concentrated by plate and frame, it is injected into the crystallization cylinder, and the above steps are repeated for cooling crystallization, centrifugal separation and drying. In this way, it is repeated four to five times. Finally, the separated mother liquor is returned to the extraction workshop after chromatographic separation for re purification. | | Production Methods | Citric acid occurs naturally in a number of plant species and may be
extracted from lemon juice, which contains 5–8% citric acid, or
pineapple waste. Anhydrous citric acid may also be produced
industrially by mycological fermentation of crude sugar solutions
such as molasses, using strains of Aspergillus niger . Citric acid is
purified by recrystallization; the anhydrous form is obtained from a
hot concentrated aqueous solution and the monohydrate from a
cold concentrated aqueous solution. | | General Description | Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061 ± 123)Jmol-1 | | Pharmaceutical Applications | Citric acid (as either the monohydrate or anhydrous material) is
widely used in pharmaceutical formulations and food products,
primarily to adjust the pH of solutions. It has also been used
experimentally to adjust the pH of tablet matrices in enteric-coated
formulations for colon-specific drug delivery. Citric acid monohydrate
is used in the preparation of effervescent granules, while
anhydrous citric acid is widely used in the preparation of
effervescent tablets. Citric acid has also been shown to improve
the stability of spray-dried insulin powder in inhalation formulations.
In food products, citric acid is used as a flavor enhancer for its
tart, acidic taste. Citric acid monohydrate is used as a sequestering
agent and antioxidant synergist. It is also a component
of anticoagulant citrate solutions. Therapeutically, preparations
containing citric acid have been used to dissolve renal calculi. | | Biochem/physiol Actions | Citric acid plays a major role in textile, food, pharmaceutical, metal and chemical industries. Melting citric acid monohydrate can give rise to itaconic anhydride. The crystals of citric acid monohydrate has the ability to preserve water up to 56 degree celsius. | | Biotechnological Applications | Citric acid monohydrate was used in the preparation of citric acid solution employed in the acetone method of 68Ga pre-purification and radiolabeling technique.
It may be used:
As release-modifying agent to improve the release of diltiazem hydrochloride from melt extruded Eudragit RS PO tablets.
To prepare citrate buffer for use in the preparation of platelets for intravital microscopy.
To prepare Tris-citrate buffer employed for the electrophoresis of bacterial enzymes. | | Safety | Citric acid is found naturally in the body, mainly in the bones, and is
commonly consumed as part of a normal diet. Orally ingested citric
acid is absorbed and is generally regarded as a nontoxic material
when used as an excipient. However, excessive or frequent
consumption of citric acid has been associated with erosion of the
teeth.
Citric acid and citrates also enhance intestinal aluminum
absorption in renal patients, which may lead to increased, harmful
serum aluminum levels. It has therefore been suggested that patients
with renal failure taking aluminum compounds to control
phosphate absorption should not be prescribed citric acid or
citrate-containing products. | | storage | Citric acid monohydrate loses water of crystallization in dry air or
when heated to about 408℃. It is slightly deliquescent in moist air.
Dilute aqueous solutions of citric acid may ferment on standing. | | Purification Methods | Crystallise it from hot H2O solution (w/w solubility is 54% at 10o, 71% at 50o and 84% at 100o. The monohydrate (softens at ~75o and melts at ~100o) dehydrates in air or when heated gently above 40o . The triethylester ( M 276.3, b 127o/1mm, 294o/atm, d 4 1.137, n D 1.4420.) is a bitter tasting oil. [Beilstein 3 H 556 and 568, 3 IV 1272.] | | Incompatibilities | Citric acid is incompatible with potassium tartrate, alkali and
alkaline earth carbonates and bicarbonates, acetates, and sulfides.
Incompatibilities also include oxidizing agents, bases, reducing
agents, and nitrates. It is potentially explosive in combination with
metal nitrates. On storage, sucrose may crystallize from syrups in
the presence of citric acid. | | Regulatory Status | GRAS listed. The anhydrous form is accepted for use as a food
additive in Europe. Included in the FDA Inactive Ingredients
Database (inhalations; IM, IV, and other injections; ophthalmic
preparations; oral capsules, solutions, suspensions and tablets;
topical and vaginal preparations). Included in nonparenteral and
parenteral medicines licensed in Japan and the UK. Included in the
Canadian List of Acceptable Non-medicinal Ingredients. |
| | Citric acid monohydrate Preparation Products And Raw materials |
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