ChemicalBook > Product Catalog >API >Synthetic Anti-infective Drugs >Antiseptics & Disinfectants Drugs >DL-Menthol

DL-Menthol

DL-Menthol Suppliers list
Company Name: Shanghai CRM New Material Technology Co., LTD
Tel:
Email: lucy@shanghaicrm.com
Products Intro: Product Name:Menthol
CAS:1490-04-6
Purity:99% Package:1KG;30USD
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:DL-Menthol
CAS:1490-04-6
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:1490-04-6
CAS:1490-04-6
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:DL-Menthol
CAS:1490-04-6
Purity:40%-99% Package:1KG;1USD
Company Name: Chengdu GLP biotechnology Co Ltd
Tel: 028-87075086
Email: scglp@glp-china.com
Products Intro: Product Name:Menthol
CAS:1490-04-6
Purity:0.98 Package:20MG;50MG;100MG;1G;5G;1KG

Lastest Price from DL-Menthol manufacturers

  • DL-Menthol
  • US $48.00 / Kg/Bag
  • 2021-09-14
  • CAS:1490-04-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 2000T
  • Menthol
  • US $0.00 / Kg/Drum
  • 2021-09-07
  • CAS:1490-04-6
  • Min. Order: 1KG
  • Purity: 99.9%
  • Supply Ability: 100000kg per month
  • DL-Menthol USP/EP/BP
  • US $1.10 / g
  • 2021-07-22
  • CAS:1490-04-6
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons min
DL-Menthol Basic information
Product Name:DL-Menthol
Synonyms:(1RS,3RS,4SR)-4 MENTHAN-3-OL;2-ISOPROPYL-5-METHYLCYCLOHEXANOL;1-Methyl-4-isopropyl-3-cyclohexanol;Menthol-d4 (Mixture of diastereoMers);DeMentholised PepperMint Oil;Mentholum racemicum;2-Isopropyl-5-methylcyclohexan-1-ol;menthanol
CAS:1490-04-6
MF:C10H20O
MW:156.27
EINECS:216-074-4
Product Categories:Flavor & essential oil;Alphabetic;M;MEA - MESAnalytical Standards;NMR Reference Standards;NMRStable Isotopes;Spectroscopy
Mol File:1490-04-6.mol
DL-Menthol Structure
DL-Menthol Chemical Properties
Melting point 34-36 °C(lit.)
Boiling point 216 °C(lit.)
density 0.89 g/mL at 25 °C(lit.)
vapor pressure 0.8 mm Hg ( 20 °C)
FEMA 2665 | MENTHOL RACEMIC
Fp 200 °F
storage temp. Sealed in dry,Room Temperature
solubility Very soluble in ethanol (95%), chloroform, ether, fatty oils and liquid paraffin; freely soluble in glacial acetic acid;soluble in acetone and benzene; very slightly soluble in glycerin; practically insoluble in water.
form neat
pka15.30±0.60(Predicted)
JECFA Number427
Stability:Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKeyNOOLISFMXDJSKH-UHFFFAOYSA-N
CAS DataBase Reference1490-04-6(CAS DataBase Reference)
NIST Chemistry ReferenceMenthol(1490-04-6)
EPA Substance Registry SystemMenthol (1490-04-6)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 37/38-41-48/20/22-40-22
Safety Statements 36/37/39-36-26
RIDADR UN 1888 6.1/PG 3
WGK Germany 2
RTECS OT0525000
HS Code 29061100
Hazardous Substances Data1490-04-6(Hazardous Substances Data)
MSDS Information
ProviderLanguage
p-Menthan-3-ol English
SigmaAldrich English
ACROS English
ALFA English
DL-Menthol Usage And Synthesis
Chemical Propertiescolourless crystals
Chemical PropertiesRacemic menthol is a mixture of equal parts of the (1R,2S,5R)- and (1S,2R,5S)-isomers of menthol. It is a free-flowing or agglomerated crystalline powder, or colorless, prismatic, or acicular shiny crystals, or hexagonal or fused masses with a strong characteristic odor and taste. The crystalline form may change with time owing to sublimation within a closed vessel. The USP 32 specifies that menthol may be either naturally occurring l-menthol or syntheti-cally prepared racemic or dl-menthol. However, the JP XV and PhEur 6.0, along with other pharmacopeias, include two separate monographs for racemic and l-menthol.
Usesmenthol is a fragrance. It is also said to be anti-septic, cooling, refreshing, and a blood-circulation stimulant. Menthol gives the skin a “cool” feeling after use. It constitutes almost 50 percent of peppermint oil but can also be synthetically produced through the hydrogenation of thymol. It is non-toxic in low doses, but in high concentrations it can be irritating to the skin, especially the mucous membranes.
UsesLabelled Menthol. Used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.
UsesMenthol is used in confectionery, perfumery, cough drops, cigarettes, liqueurs, etc.; topical antipruritic; local anesthetic; gastric sedative.
DefinitionA white crystalline terpenealcohol, C10H19OH; r.d. 0.89;m.p. 42°C; b.p. 103–104°C. It has aminty taste and is found in certainessential oils (e.g. peppermint) andused as a flavouring.
Production MethodsMenthol occurs widely in nature as l-menthol and is the principal component of peppermint and cornmint oils obtained from the Mentha piperita and Mentha arvensis species. Commercially, lmenthol is mainly produced by extraction from these volatile oils. It may also be prepared by partial or total synthetic methods.
Racemic menthol is prepared synthetically via a number of routes, e.g. by hydrogenation of thymol.
DefinitionChEBI: Any secondary alcohol that is one of the eight possible diastereoisomers of 5-methyl-2-(propan-2-yl)cyclohexan-1-ol.
Brand nameFisherman’s Friend Lozenges (Bristol-Myers Products); Therapeutic Mineral Ice (Bristol-Myers Products).
Pharmaceutical ApplicationsMenthol is widely used in pharmaceuticals, confectionery, and toiletry products as a flavoring agent or odor enhancer. In addition to its characteristic peppermint flavor, l-menthol, which occurs naturally, also exerts a cooling or refreshing sensation that is exploited in many topical preparations. Unlike mannitol, which exerts a similar effect due to a negative heat of solution, l-menthol interacts directly with the body’s coldness receptors. d-Menthol has no cooling effect, while racemic menthol exerts an effect approximately half that of l-menthol.
When used to flavor tablets, menthol is generally dissolved in ethanol (95%) and sprayed onto tablet granules and not used as a solid excipient.
Menthol has been investigated as a skin-penetration enhancer and is also used in perfumery, tobacco products, chewing gum and as a therapeutic agent. When applied to the skin, menthol dilates the blood vessels, causing a sensation of coldness followed by an analgesic effect. It relieves itching and is used in creams, lotions, and ointments. When administered orally in small doses menthol has a carminative action.
SafetyAlmost all toxicological data for menthol relate to its use as a therapeutic agent rather than as an excipient. Inhalation or ingestion of large quantities can result in serious adverse reactions such as ataxia and CNS depression,hypersensitivity reactions, severe abdominal pain, nausea, vomiting, vertigo, drowsiness, and coma.Although menthol is essentially nonirritant there have been some reports of hypersensitivity following topical application. In a Polish study approximately 1% of individuals were determined as being sensitive to menthol.There have been reports of apnea and instant collapse in infants after the local application of menthol to their nostrils.
The WHO has set an acceptable daily intake of menthol at up to 0.4 mg/kg body-weight.
LD50 (rat, IM): 10.0 g/kg
LD50 (rat, oral): 3.18 g/kg
storageA formulation containing menthol 1% w/w in aqueous cream has been reported to be stable for up to 18 months when stored at room temperature.
Menthol should be stored in a well-closed container at a temperature not exceeding 25°C, since it sublimes readily.
IncompatibilitiesIncompatible with: butylchloral hydrate; camphor; chloral hydrate; chromium trioxide; b-naphthol; phenol; potassium permanganate; pyrogallol; resorcinol; and thymol.
Regulatory StatusIncluded in the FDA Inactive Ingredients Database (dental preparations, inhalations, oral aerosols, capsules, solutions, suspensions, syrups, and tablets; also topical preparations). Included in nonparenteral medicines licensed in the UK. Accepted for use in foods and confectionery as a flavoring agent of natural origin. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
DL-Menthol Preparation Products And Raw materials
Tag:DL-Menthol(1490-04-6) Related Product Information
Menthol nonanoate,5-Methyl-2-(1-methylethyl)cyclohexanol nonanoate 4-Methyl-1-(1-methylethyl)cyclohexanol 5-Methyl-2-(1-methylethyl)cyclohexanol tetradecanoate,Menthol tetradecanoate Sodium cholate Taurodeoxycholic acid sodium salt DIGITOXIGENIN 20(22),5BETA-CARDENOLID-3BETA,14BETA,16BETA-TRIOL 3,16-DIACETATE 11-BETA-HYDROXYANDROSTERONE 11ALPHA-HYDROXYPROGESTERONE ALLOTETRAHYDROCORTISOL (-)-MENTHOXYACETIC ACID Ursodeoxycholic acid l-Menthol acetate CYMARIN DL-Menthol ISOPROPYL LAURATE Cyclohexanol Methyl