ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
中文名称 | ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈 |
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中文同义词 | ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈;2,2-二苯基-5-(4-((吡啶-3-基亚甲基)氨基)哌嗪-1-基)戊腈;SC-26196,A Δ6去饱和酶抑制剂 |
英文名称 | α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile |
英文同义词 | SC 26196;α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile;alpha,alpha-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile;α,α-Diphenyl-4-[(3-pyridinylMethylene)aMino]-1-piperazine;2,2-diphenyl-5-{4-[(E)-(pyridin-3-ylMethylidene)aMino]piperazin-1-yl}pentanenitrile;PF-o6341724;(E)-2,2-diphenyl-5-(4-((pyridin-3-ylMethylene)aMino)piperazin-1-yl)pentanenitrile;2,2-diphenyl-5-(4-[[(1 E)-pyridin-3-yl-methylidene]amino]piperazin-1-yl)pentanenitrile |
CAS号 | 218136-59-5 |
分子式 | C27H29N5 |
分子量 | 423.55 |
EINECS号 | |
相关类别 | 试剂;Selective Δ6 desaturase inhibitor. |
Mol文件 | 218136-59-5.mol |
结构式 |
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈 性质
储存条件 | 2-8°C |
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溶解度 | 二甲基亚砜:≥10mg/mL |
形态 | 粉末 |
颜色 | 白色至棕褐色 |
IC50: 0.2 µM (Delta6 desaturase in a rat liver microsomal assay)
SC-26196 (200 nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells.
Cell Proliferation Assay
Cell Line: | PBMCs and Jurkat cells |
Concentration: | 200 nM |
Incubation Time: | 96 hours for PBMCs; 144 hours for Jurkat cells |
Result: |
Treatment of PBMCs significantly decreased the proportion of cells that underwent division, the division index and proliferation index.
Did not alter cell proliferation significantly in Jurkat cells. |
SC-26196 ( included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme.
Animal Model: | Male mice (12- or 15-week-old) |
Dosage: | 0, 10, 30, and 100 mg/kg per day |
Administration: | Included in the diet at 0, 0.07, 0.21, or 0.7mg/kg diet to achieve dosages of 0, 10, 30, and 100mg/kg per day. |
Result: | Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. |
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-107410 | SC-26196 | 1 mg | 522元 | |
2024/08/19 | HY-107410 | ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈 SC-26196 | 218136-59-5 | 5mg | 1150元 |