SC 66
中文名称 | SC 66 |
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中文同义词 | (2E,6E)-2,6-二(4-吡啶基亚甲基)环己酮;AKT抑制剂(SC66);化合物SC66 |
英文名称 | SC 66 |
英文同义词 | SC 66;Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-;(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone;CS-2480;SC66;SC 66;(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone;Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis |
CAS号 | 871361-88-5 |
分子式 | C18H16N2O |
分子量 | 276.33 |
EINECS号 | |
相关类别 | 细胞生物学试剂 |
Mol文件 | 871361-88-5.mol |
结构式 |
SC 66 性质
储存条件 | Sealed in dry,2-8°C |
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溶解度 | DMSO:≥5mg/mL(加热) |
形态 | 粉末 |
颜色 | 淡黄色至深黄色 |
Akt
|
SC66 inhibits cell viability and colony forming capacity of HCC cells with IC 50 s of 0.77,0.47,0.92,0.75 and 2.85 μg/mL at 72 hours for HepG2, Hep3B, PLC/PRF/5,HA22T/VGH and Huh7 cells. HepG2, HA22T/VGH and PLC/PRF/5 cells have similar IC 50 s of approximately 0.85 and 0.75 μg/mL at 48 and 72 hours, respectively. To determine whether the decrease in cell viability is related to apoptosis induction, TUNEL assays are performed in Hep3B and Huh7 cells treated with 1, 2 and 4 μg/mL of SC66 for 24 hours. In Hep3B cells the number of TUNEL-positive cells increased with increasing concentrations of SC66, whereas in Huh7 cells very few light brown-colored cells are observed only after treatment with 4 μg/mL SC66.
To demonstrate the effectiveness in vivo of SC66 on HCC, a mouse xenograft tumor model of Hep3B cells is used. When tumors became palpable, at a size of about 150 mm 3 , mice are randomized into three groups of 6 animals each. The treated group receive SC66 at 15 and 25 mg/kg twice a week via i.p. injection, while the untreated group receive the vehicle alone. Treatment with 25 mg/Kg SC66 significantly reduces tumor volume to 37% on day 17 when compared with tumors of the untreated group.
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-19832 | SC 66 SC66 | 871361-88-5 | 5mg | 550元 |
2024/01/25 | HY-19832 | SC 66 SC66 | 871361-88-5 | 10mM * 1mLin DMSO | 605元 |