ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
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- CAS号:
- 218136-59-5
- 英文名:
- α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
- 英文别名:
- CS-117;SC 26196;PF-o6341724;SC26196;SC 26196;SC 26196 - PF 06341724;α,α-Diphenyl-4-[(3-pyridinylMethylene)aMino]-1-piperazine;a,a-diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile;α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile;α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile;1-Piperazinepentanenitrile, α,α-diphenyl-4-[(3-pyridinylmethylene)amino]-
- 中文名:
- ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
- 中文别名:
- SC-26196,A Δ6去饱和酶抑制剂;2,2-二苯基-5-(4-((吡啶-3-基亚甲基)氨基)哌嗪-1-基)戊腈;ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
- CBNumber:
- CB12518849
- 分子式:
- C27H29N5
- 分子量:
- 423.55
- MOL File:
- 218136-59-5.mol
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ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥10mg/mL
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形态:
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powder
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颜色:
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white to tan
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ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈性质、用途与生产工艺
SC-26196 是一种有效的，具有口服活性的 Delta6 去饱和酶 (D6D, FADS2) 抑制剂 (在大鼠肝微粒体中，IC50=0.2 µM)。具有抗炎活性。
SC-26196 是一种有效的，具有口服活性的 Delta6 去饱和酶 (D6D, FADS2) 抑制剂 (在大鼠肝微粒体中，IC50=0.2 µM)。具有抗炎活性。
IC50: 0.2 µM (Delta6 desaturase in a rat liver microsomal assay)
SC-26196 (200 nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells.
Cell Proliferation Assay
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Cell Line:
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PBMCs and Jurkat cells
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Concentration:
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200 nM
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Incubation Time:
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96 hours for PBMCs; 144 hours for Jurkat cells
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Result:
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Treatment of PBMCs significantly decreased the proportion of cells that underwent division, the division index and proliferation index.
Did not alter cell proliferation significantly in Jurkat cells.
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SC-26196 ( included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme.
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Animal Model:
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Male mice (12- or 15-week-old)
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Dosage:
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0, 10, 30, and 100 mg/kg per day
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Administration:
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Included in the diet at 0, 0.07, 0.21, or 0.7mg/kg diet to achieve dosages of 0, 10, 30, and 100mg/kg per day.
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Result:
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Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver.
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ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-107410 | SC-26196 | | 1 mg | 522元 |
| 2024/04/30 | S0886 | ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
SC-26196 | 218136-59-5 | 5mg | 1040.13元 |
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
生产厂家
218136-59-5, ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈 相关搜索:
- Selective Δ6 desaturase inhibitor.
- 药靶配体
- 试剂
- C27H29N5
- SC-26196,A Δ6去饱和酶抑制剂
- 2,2-二苯基-5-(4-((吡啶-3-基亚甲基)氨基)哌嗪-1-基)戊腈
- ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
- 218136-59-5
- α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
- 2,2-Diphenyl-5-(4-((pyridin-3-ylmethylene)amino)piperazin-1-yl)pentanenitrile
- 1-Piperazinepentanenitrile, α,α-diphenyl-4-[(3-pyridinylmethylene)amino]-
- SC26196;SC 26196
- CS-117
- SC 26196 - PF 06341724
- a,a-diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
- 2,2-diphenyl-5-(4-[[(1 E)-pyridin-3-yl-methylidene]amino]piperazin-1-yl)pentanenitrile
- (E)-2,2-diphenyl-5-(4-((pyridin-3-ylMethylene)aMino)piperazin-1-yl)pentanenitrile
- PF-o6341724
- 2,2-diphenyl-5-{4-[(E)-(pyridin-3-ylMethylidene)aMino]piperazin-1-yl}pentanenitrile
- α,α-Diphenyl-4-[(3-pyridinylMethylene)aMino]-1-piperazine
- alpha,alpha-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
- α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
- SC 26196