BIS(METHYLTHIO)GLIOTOXIN

BIS(METHYLTHIO)GLIOTOXIN Suppliers list
Company Name: Shaanxi Pioneer Biotech Co., Ltd .
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Email: sales@pioneerbiotech.com
Products Intro: Product Name:Bisdethiobis(methylthio)gliotoxin
CAS:74149-38-5
Purity:0.99 Package:1g;25g;1kg;25kg;100kg
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Bisdethiobis(methylthio)gliotoxin
CAS:74149-38-5
Package:1 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: BioBioPha Co., Ltd.  
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Products Intro: Product Name:Bisdethiobis(methylthio)gliotoxin
CAS:74149-38-5
Package:5mg Remarks:BBP04311
Company Name: ALB Technology Limited  
Tel: 702-983-3769
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Products Intro: Product Name:Bisdethiobis(methylthio)gliotoxin
CAS:74149-38-5
Purity:95% Package:5mg-1g Remarks:Item No.: ALB-RS-4768
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885
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Products Intro: Product Name:Bis(methylthio)gliotoxin
CAS:74149-38-5
Purity:>99% Package:1mg
BIS(METHYLTHIO)GLIOTOXIN Basic information
Product Name:BIS(METHYLTHIO)GLIOTOXIN
Synonyms:gliotoxin, bis-dethio-bis(methylthio)-;(3R)-2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3α,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;Bis(methylthio)gliotoxin (FR-49175);BIS(METHYLTHIO)GLIOTOXIN;FR-49175;bis-dethio-bis(methylthio)gliotoxin;Pyrazino[1,2-a]indole-1,4-dione, 2,3,5a,6,10,10a-hexahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylthio)-, (3R,5aS,6S,10aR)-
CAS:74149-38-5
MF:C15H20N2O4S2
MW:356.46
EINECS:
Product Categories:
Mol File:74149-38-5.mol
BIS(METHYLTHIO)GLIOTOXIN Structure
BIS(METHYLTHIO)GLIOTOXIN Chemical Properties
Boiling point 669.6±55.0 °C(Predicted)
density 1.49±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka12.69±0.60(Predicted)
form White solid.
color Off-White to Yellow
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
Safety Statements 36
RIDADR 1544
HazardClass 6.1(b)
PackingGroup III
MSDS Information
BIS(METHYLTHIO)GLIOTOXIN Usage And Synthesis
DescriptionBis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 μM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC50s = >400 μM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 μM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD50 = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.
UsesBis(methylthio)gliotoxin (FR-49175) is an antiphagocytic metabolite.
Enzyme inhibitorThis naturally occurring indole derivative (FW = 356.47 g/mol; CAS 74149- 38-5), also known as bis(methylthio)gliotoxin and dimethylgliotoxin, is a platelet-acivating factor (PAF) antagonist that inhibits PAF-induced platelet aggregation. The parent compound, gliotoxin is a dual inhibitor of famesyltransferase and geranylgeranyl-transferase. Bisdethiobis(methylthio)gliotoxin is a minor metabolite of Gliocladium deliquescens, Radiocarbon tracer experiments showed it is formed, apparently irreversibly, from gliotoxin. It has also been synthesized from gliotoxin by reduction and methylation. Bisdethio-bis(methylthio)gliotoxin also binds Cu+ and Ag+ ions.
BIS(METHYLTHIO)GLIOTOXIN Preparation Products And Raw materials
Tag:BIS(METHYLTHIO)GLIOTOXIN(74149-38-5) Related Product Information
(S)-1-ISOPROPYL-2-METHYL-PIPERAZINE 1-Methylpiperazin-2-one 1-ISOPROPYL-PIPERAZIN-2-ONE CYCLO(-ALA-ALA) HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE 1,2,4-TRIMETHYLDIETHYLENEDIAMINE 1-ETHYLPIPERAZIN-2-ONE BIS(METHYLTHIO)GLIOTOXIN 2-Piperazinemethanol 3-ETHYL-PIPERAZIN-2-ONE CYCLO(-ALA-SER) CIS-2,5-DIMETHYLPIPERAZINE 2-Aminoethyldiisopropylamine 4-(2-HYDROXYETHYL)-PIPERAZIN-2-ONE N,N'-Diisopropylethylenediamine hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one (R)-2-ETHYL-PIPERAZINE 1-(2-BUTYL)-PIPERAZINE