| Company Name: |
BioBioPha Co., Ltd.
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| Tel: |
0871-65217109 13211707573; |
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y.liu@mail.biobiopha.com |
| Products Intro: |
Product Name:Bisdethiobis(methylthio)gliotoxin
CAS:74149-38-5
Package:5mg Remarks:BBP04311
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| Company Name: |
ALB Technology Limited
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| Tel: |
702-983-3769 |
| Email: |
sales@albtechnology.com |
| Products Intro: |
Product Name:Bisdethiobis(methylthio)gliotoxin
CAS:74149-38-5
Purity:95% Package:5mg-1g Remarks:Item No.: ALB-RS-4768
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| | BIS(METHYLTHIO)GLIOTOXIN Basic information |
| Product Name: | BIS(METHYLTHIO)GLIOTOXIN | | Synonyms: | gliotoxin, bis-dethio-bis(methylthio)-;(3R)-2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3α,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;Bis(methylthio)gliotoxin (FR-49175);BIS(METHYLTHIO)GLIOTOXIN;FR-49175;bis-dethio-bis(methylthio)gliotoxin;Pyrazino[1,2-a]indole-1,4-dione, 2,3,5a,6,10,10a-hexahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylthio)-, (3R,5aS,6S,10aR)- | | CAS: | 74149-38-5 | | MF: | C15H20N2O4S2 | | MW: | 356.46 | | EINECS: | | | Product Categories: | | | Mol File: | 74149-38-5.mol |  |
| | BIS(METHYLTHIO)GLIOTOXIN Chemical Properties |
| Boiling point | 669.6±55.0 °C(Predicted) | | density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | White solid. | | pka | 12.69±0.60(Predicted) | | color | Off-White to Yellow |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | RIDADR | 1544 | | HazardClass | 6.1(b) | | PackingGroup | III |
| | BIS(METHYLTHIO)GLIOTOXIN Usage And Synthesis |
| Description | Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 μM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC50s = >400 μM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 μM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD50 = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis. | | Uses | Bis(methylthio)gliotoxin (FR-49175) is an antiphagocytic metabolite. | | Enzyme inhibitor | This naturally occurring indole derivative (FW = 356.47 g/mol; CAS 74149- 38-5), also known as bis(methylthio)gliotoxin and dimethylgliotoxin, is a platelet-acivating factor (PAF) antagonist that inhibits PAF-induced platelet aggregation. The parent compound, gliotoxin is a dual inhibitor of famesyltransferase and geranylgeranyl-transferase. Bisdethiobis(methylthio)gliotoxin is a minor metabolite of Gliocladium deliquescens, Radiocarbon tracer experiments showed it is formed, apparently irreversibly, from gliotoxin. It has also been synthesized from gliotoxin by reduction and methylation. Bisdethio-bis(methylthio)gliotoxin also binds Cu+ and Ag+ ions. |
| | BIS(METHYLTHIO)GLIOTOXIN Preparation Products And Raw materials |
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