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| | 2,3,4-Trihydroxybenzaldehyde Basic information |
| Product Name: | 2,3,4-Trihydroxybenzaldehyde | | Synonyms: | 2,3,4-TRIHYDROXYBENZALDEHYDE;2,3,4-Trihydroxybenzaldehyde,98%;2,3,4-TRIHYDROXYBENZALDEHYDE 98%;PYROGALLOLALDEHYDE;PYROGALLOL-4-CARBOXALDEHYDE;2,3,4-THB;Pyrogallolcarboxaldehyde;2,3,4-Trihydroxybenzaldehyde,Pyrogallol-4-carboxaldehyde | | CAS: | 2144-08-3 | | MF: | C7H6O4 | | MW: | 154.12 | | EINECS: | 218-404-2 | | Product Categories: | Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;2144-08-3 | | Mol File: | 2144-08-3.mol |  |
| | 2,3,4-Trihydroxybenzaldehyde Chemical Properties |
| Melting point | 159-161 °C (lit.) | | Boiling point | 237.46°C (rough estimate) | | density | 1.3725 (rough estimate) | | refractive index | 1.6400 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO, Methanol | | form | Powder | | pka | 7.41±0.23(Predicted) | | color | Light brown to beige-brown | | Water Solubility | 1.541g/L at 25℃ | | Sensitive | Air Sensitive | | BRN | 2328658 | | LogP | 1.25 | | CAS DataBase Reference | 2144-08-3(CAS DataBase Reference) | | EPA Substance Registry System | Benzaldehyde, 2,3,4-trihydroxy- (2144-08-3) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-36 | | WGK Germany | 2 | | RTECS | CU8439800 | | TSCA | Yes | | HS Code | 29124990 |
| | 2,3,4-Trihydroxybenzaldehyde Usage And Synthesis |
| Description |
2,3, 4-trihydroxybenzaldehyde is an essential intermediate of the antiparkinson drug benserazide, which is a peripheral dopa decarboxylase inhibitor, usually benserazide: the L-dopa is prepared into a compound preparation at a ratio of 1:4, and has a remarkable effect of treating the Parkinson's disease.
| | Chemical Properties | light brown to beige-brown powder | | Uses | 2,3,4-Trihydroxybenzaldehyde has been used in the preparation of 1,5-dimethyl-2-phenyl-4-[(1E)-(2,3,4-trihydroxybenzylidene)amino]-1H-pyrazol-3(2H)-one. | | Uses | 2,3,4-Trihydroxybenzaldehyde is a phenolic benzaldehyde with antibacterial activity. | | General Description | Antimicrobial activity of carbohydrazone derived from 2,3,4-trihydroxybenzaldehyde against bacteria and fungi has been investigated. 2,3,4-trihydroxybenzaldehyde forms Schiff bases via [1+1] condensation with anthranilic acid. | | Synthesis |
The method for synthesizing 2,3, 4-trihydroxybenzaldehyde is shown as follows.
 This method takes pyrogallol as an initial raw material. It comprises three steps of phenolic hydroxyl protection, formylation, and deprotection: protecting two adjacent phenolic hydroxyl groups in the pyrogallol to obtain 4-hydroxybenzo[d][1,3]dioxol-2-one, then performing formylation to obtain 7-hydroxy-2-oxobenzo[d][1,3]dioxole-4-carbaldehyde, and finally removing a protecting group to get a target 2,3,4-trihydroxybenzaldehyde.
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| | 2,3,4-Trihydroxybenzaldehyde Preparation Products And Raw materials |
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