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Sodium risedronate

Sodium risedronate Suppliers list
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Products Intro: Product Name:Risedronate sodium
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
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Products Intro: Product Name:Risedronate Sodium
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Products Intro: Product Name:Sodium risedronate
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Products Intro: Product Name:Sodium risedronate
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Sodium risedronate manufacturers

  • Sodium risedronate
  • $0.00 / 1KG
  • 2023-02-08
  • CAS:115436-72-1
  • Min. Order: 50KG
  • Purity: 99%
  • Supply Ability: 500000kg
  • Sodium risedronate
  • $5.00 / 1KG
  • 2022-01-14
  • CAS:115436-72-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 5t
  • Sodium risedronate
  • $10.00 / 1Kg/Bag
  • 2021-11-03
  • CAS:115436-72-1
  • Min. Order: 1Kg/Bag
  • Purity: 99%
  • Supply Ability: 20 Tons
Sodium risedronate Basic information
Description References
Product Name:Sodium risedronate
Synonyms:RISEDREMATE SODIUM;RISEDRONATE NA;RISEDRONATE SODIUM;RISEDRONIC ACID, SODIUM SALT;SODIUM RISEDRONATE;[1-hydroxy-2-(3-pyridinyl)ethylidene]-bis[phosphonic acid] monosodium salt;(1-hydroxy-2-(3-pyridinyl)ethylidene)bis-phosphonicacimonosodiumsalt;risedronate,RID
Product Categories:BELCOMYCINE;All Inhibitors;Osteoporosis;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Active Pharmaceutical Ingredients;Bone Resorption Inhibitor;Phosphorylating and Phosphitylating Agents;Heterocycles
Mol File:115436-72-1.mol
Sodium risedronate Structure
Sodium risedronate Chemical Properties
Melting point 252-262°C
storage temp. room temp
solubility H2O: soluble5mg/mL, clear (warmed)
form powder
color white to beige
CAS DataBase Reference115436-72-1(CAS DataBase Reference)
Safety Information
Risk Statements 62-64
Safety Statements 20-22-36/37
WGK Germany 3
RTECS SZ8567500
HS Code 29333990
MSDS Information
Sodium risedronate Usage And Synthesis
DescriptionRisedronate sodium is a nitrogen-containing bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism.
Risedronate sodium is used for the treatment of postmenopausal osteoporosis to reduce the risk of vertebral fractures, treatment of established postmenopausal osteoporosis to reduce the risk of hip fractures, treatment of osteoporosis in men at high risk of fractures, and treatment of Paget’s disease. It is marketed as Actonel (tablet) and Atelvia (delayed-release tablet).
DescriptionRisedronate sodium was launched as Actonel in the US for treatment of Paget's disease. Risedronic acid is readily obtained by condensation of 2-(3- pyridyl)acetic acid with phosphorous acid in presence of phosphorus oxychloride. Risedronate sodium is an orally active bisphosphonate of third generation, showing more potent bone antiresorptive properties than most of prior bisphosphonates like etidronate which has been used for the same indication since 1978. The biological mechanism by which Risedronate, and generally bisphosphonates, act is not quite clear presently ; recent advances have suggested that aminobisphosphonates interfere with the HMG-CoA pathway and inhibit protein prenylation, causing apoptosis of osteoclasts and macrophages. These apoptotic effects are correlated to the anti-resorptive properties of this class of compounds. In a 2 month clinical trial involving patients with Paget's desease, 30 mg risedronate daily achieved an appreciable reduction of serum alkaline phosphatase levels, an indicator of bone stabilization, in 77% of patients, compared with 11% on etidronate at 400 mg daily for 6 months. Risedronate is also in development for the treatment and prevention of various bone diseases, particularly post-menopausal and corticosteroid-induced osteoporosis.
Chemical PropertiesFine White to Off-White Crystalline Powder
OriginatorProcter Gamble (US)
UsesRisedronic Acid is a pyridinyl biphosphonate bone resorption inhibitor.
Brand nameActonel (Procter & Gamble).
HazardHuman systemic effects.
Biological ActivityOrally active biphosphonate that inhibits farnesyl diphosphate (FPP) synthase. Exhibits antiproliferative and proapoptotic activity in numerous tumor cell lines and inhibits osteoclast-mediated bone reabsorption in vivo .
Biochem/physiol ActionsRisedronate sodium is a bisphosphonate bone resorption inhibitor. It has an affinity for hydroxyapatite crystals in bone and acts as an antiresorptive agent and is an inhibitor of farnesyl diphosphate (FPP) synthase, which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. Risedronate sodium has been used to treat postmenopausal osteoporosis and Paget′s disease.
Clinical UseBisphosphonate:
Treatment and prevention of osteoporosis (including corticosteroid induced)
Paget’s disease
Drug interactionsPotentially hazardous interactions with other drugs
Calcium-containing substances: avoid for 2 hours before and after administration.
MetabolismThe mean bioavailability of risedronate is 0.63% in the fasting state, and there is no evidence of systemic metabolism of risedronate sodium.
About half of the absorbed portion is excreted in the urine within 24 hours; the remainder is sequestered to bone for a prolonged period. Unabsorbed drug is eliminated unchanged in the faeces.
Sodium risedronate Preparation Products And Raw materials
Tag:Sodium risedronate(115436-72-1) Related Product Information
Sodium chloride Foscarnet sodium Risedronic acid Ibandronate sodium monohydrate 1-Hydroxyethylidene-1,1-diphosphonic acid 1-Hydroxyethanediphosphonic acid sodium salt Sodium citrate NE 58095-d4 NE 58095-d Etidronic acid monohydrate Pamidronate disodium salt Sodium risedronate Alendronate sodium Clodronate disodium Disodium pamidronate CHLOROPHOSPHONAZO III sodium Ascoric Acid