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Diclofenac sodium

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Company Name: Beijing Yibai Biotechnology Co., Ltd
Tel: 0086-182-6772-3597
Email: sales03@yibaibiotech.com
Products Intro: Product Name:Diclofenac Sodium
CAS:15307-79-6
Purity:99% Package:1g;0USD|1KG;0USD|10KG;0USD|100KG|1T
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
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Products Intro: Product Name:Diclofenac sodium
CAS:15307-79-6
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: PI & PI BIOTECH INC.
Tel: 18371201331
Email: Sales@pipitech.com
Products Intro: Product Name:Diclofenac Sodium
CAS:15307-79-6
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:Chemical Formula: C14H10Cl2NNaO2|sodium2-((2,6-dichlorophenyl)amino)benzeneacetic acid
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
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Products Intro: Product Name:Diclofenac Sodium 15307-79-6
CAS:15307-79-6
Purity:99% Package:1KG;10USD
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: Product Name:Diclofenac sodium
CAS:15307-79-6
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG

Lastest Price from Diclofenac sodium manufacturers

  • Diclofenac sodium
  • US $1.00-1.00 / KG
  • 2020-05-12
  • CAS:15307-79-6
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
  • Diclofenac sodium
  • US $1.00-1.00 / KG
  • 2020-05-12
  • CAS:15307-79-6
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons

Related articles

  • What is Diclofenac sodium?
  • Diclofenac is a phenylacetic acid derivative belonging to the class of the non-selective non-steroidal anti-inflammatory drugs....
  • Feb 11,2020
Diclofenac sodium Basic information
Uses Mechanisms of action Clinical Application
Product Name:Diclofenac sodium
Synonyms:sodium 2-[2-(2,6-dichloroanilino)phenyl]acetate;2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium;Diclofenac Sodium - CAS 15307-79-6 - Calbiochem;sodium(o-((2,6-dichlorophenyl)amino)phenyl)acetate;sodium(o-(2,6-dichloroanilino)phenyl)acetate;sodiumdiclofenac;tsudohmin;AKOS B020028
CAS:15307-79-6
MF:C14H10Cl2NNaO2
MW:318.13
EINECS:239-346-4
Product Categories:API's;Lipid signaling;Amines;Aromatics;Heterocycles;VOLATREN;Other APIs;Active Pharmaceutical Ingredients;Organics;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
Mol File:15307-79-6.mol
Diclofenac sodium Structure
Diclofenac sodium Chemical Properties
Melting point 288-290°C
density 0.781 g/cm3
storage temp. -20°C Freezer
solubility H2O: 50 mg/mL
pka4(at 25℃)
form White solid
Water Solubility Soluble in water to 50mg/ml.
Merck 14,3081
Stability:Stable.
InChIKeyKPHWPUGNDIVLNH-UHFFFAOYSA-M
CAS DataBase Reference15307-79-6(CAS DataBase Reference)
Safety Information
Hazard Codes T,Xi
Risk Statements 25-36/37/38-63
Safety Statements 22-36/37-45-36-26-60-20
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS AG6330000
HazardClass 6.1(b)
PackingGroup III
HS Code 29224999
ToxicityLD50 in mice, rats (mg/kg): ~390, 150 orally (Krupp)
MSDS Information
Diclofenac sodium Usage And Synthesis
Uses

Diclofenac is a phenylacetic acid derivative belonging to the class of the non-selective non-steroidal anti-inflammatory drugs (NSAIDs). It exhibits analgesic, antipyretic and anti-inflammatory activity. Due to its poor solubility, the parenteral formulation of diclofenac sodium (Voltarol ampoules) currently available in Europe contains the solvents propylene glycol and benzyl alcohol that allows intramuscular and intravenous administration. Diclofenac sodium has long been used to treat acute pain and inflammation, and is effective in various acute forms of pain.

Mechanisms of action

Putative mechanisms of action of diclofenac may include inhibition of leukotriene synthesis, inhibition of phospholipase A2, modulation of free arachidonic acid levels, stimulation of adenosine triphosphate-sensitive potassium channels via the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway and centrally mediated and neuropathic mechanisms. Other emerging mechanisms of action may include inhibition of peroxisome proliferator activated receptor-c, reduction in plasma and synovial substance P and interleukin-6 levels, inhibition of the thromboxane-prostanoid receptor and inhibition of acid-sensing ion channels.

Clinical Application

Clinical trials have demonstrated the analgesic efficacy of diclofenac sodium in terms of relieving moderate to severe postoperative pain in patients undergoing dental surgery or minor orthopaedic surgery. Subcutaneous diclofenac sodium also effectively relieved moderate to severe neuropathic pain, related to cancer or not. Diclofenac sodium was generally well tolerated in clinical trials, with injection-site reactions among the most commonly reported adverse events.

Chemical PropertiesOff-White Crystalline Solid
UsesA nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.
UsesAn inhibitor of Cox-1 and Cox-2.
UsesA nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor
DefinitionChEBI: The sodium salt of diclofenac.
Brand nameSolaraze (Bioglan); Voltaren (Novartis);Aflamin;Alfamin;Allvoran;Artren;Blesin;B-voltaren;Cgp 9194;Chlorgyl;Ct-diclo;Dichloronic;Diclo attritin;Diclo spondril;Diclo-attritin;Diclo-burg;Diclo-phlohont;Diclo-puren;Diclo-recip;Dicloreum;Diclo-spondyril;Diclo-wolf;Dolobasan;Dolotrem;Doragon;Duravolten;Duvavotten;Feloran;Fenoflam;Flogofenac;Flogogenac;Forgenac;Inflamac;Klast;Monoflam;Myogit;Neuro-effekton;Neurofenac;Neuro-voltaren;Neviodin;Olfen;Panamor;Rewodina;Rheumalgen;Rheumavincin-n;Seecoren;Shignol;Silino;Sofarin;Thicataren;Toryxil;Tsudomin;Voltarene.
World Health Organization (WHO)The World Health Organization currently has no information to suggest that diclofenac is less safe than other widely available non-steroidal antiinflammatory substances of this type, or that children are particularly liable to react adversely. It is registered in many countries in several dosage forms, including a 12.5 mg suppository indicated for juvenile arthritis.
Veterinary Drugs and TreatmentsThe equine topical cream (Surpass?) is labeled for the control of pain and inflammation associated with osteoarthritis in tarsal, carpal, metacarpophalangeal, metarsophalangeal, and proximal interphalangeal (hock, knee, fetlock, pastern) joints for use up to 10 days duration. While, theoretically, diclofenac could be used systemically (orally) in other veterinary species, there are approved and safer alternatives.
Diclofenac sodium Preparation Products And Raw materials
Raw materialsEthanol-->Aniline-->Chloroacetyl chloride-->2-Chlorobenzoic acid-->2-Chlorotoluene-->2,6-Dichlorophenol-->2,5-Dichloroaniline
Tag:Diclofenac sodium(15307-79-6) Related Product Information
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