布替萘芬
中文名称 | 布替萘芬 |
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中文同义词 | N-甲基-N-(萘-1-基甲基)-1-(4-叔丁基苯基)甲胺;布替萘芬;布替萘芬 布替萘芬中间体;布替萘芬杂质 |
英文名称 | Butenafine |
英文同义词 | n-methyl-n-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine;n-(p-tert-butylbenzyl)-n-methyl-1-naphthalenemethylamine;N-methyl-N-(4-methylbenzyl)-N-(1-naphthylmethyl)amine;4-tert-Butylbenzylmethyl 1-naphtylmethylamine;N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine;(4-tert-butylbenzyl)-methyl-(1-naphthylmethyl)amine;BUTENAFINE;1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine |
CAS号 | 101828-21-1 |
分子式 | C23H27N |
分子量 | 317.47 |
EINECS号 | |
相关类别 | 抗菌,皮肤外用;原料 |
Mol文件 | 101828-21-1.mol |
结构式 |
布替萘芬 性质
熔点 | 200-202 °C |
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沸点 | 426.1±14.0 °C(Predicted) |
密度 | 1.032±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO:63 mg/mL (198.44 mM);乙醇:63 mg/mL (198.44 mM) |
酸度系数(pKa) | 7.87±0.50(Predicted) |
水溶解性 | Water: Insoluble |
LogP | 6.770 (est) |
CAS 数据库 | 101828-21-1(CAS DataBase Reference) |
IC50: antifungal
Butenafine demonstrates comparable activity against the dermatophytes with a MIC range of 0.03-0.25 μg/ml. It displays limited activity against the yeast Candida albicans and no activity against Malassezia furfur .Butenafine (25; 50 or 100 μM) eliminates the promastigote forms of L. amazonensis and L. braziliensis in a dose-dependent manner, and shows EC 50 values of 34.10±3.76 μM and 81.25±10.24 μM, respectively, in peritoneal macrophages from BALB/c mice. Butenafine induces mild cytotoxicity in peritoneal macrophages from BALB/c mice with a CC 50 of 97.88 μM.
Butenafine (subcutaneous administration; 1-100 mg/kg) to mice has no effect on the central and autonomic nervous systems. Topical administration of 0.3-3.0% butenafine solutions to guinea pigs also has no effect on the somatic nervous system.In primary therapeutic studies on guinea pigs, Butenafine (1% topical application; 4-10 days; day 3 and 4 post-infection) exhibits a complete cure after 10 days in vivo-effect on dermatophytosis, T. mentagrophytes .Butenafine (0.125, 0.25, 0.5 and 1.0% topical application; q.d. or b.i.d. for 10 days; day 4 post-infection) exhibits a 100% cure after 0.5% or 1% application and has no difference in efficacy between 1% q.d. and b.i.d. in vivo-effect on dermatophytosis, T. mentagrophytes.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | S5944 | 布替萘芬 Butenafine | 101828-21-1 | 25mg | 876.8元 |
2024/08/19 | S5944 | Butenafine | 101828-21-1 | 1g | 7944.3元 |