9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物)
中文名称 | 9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物) |
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中文同义词 | 9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤;9-(R)-2-(磷酰甲氧基)丙基腺嘌呤(R-PMPA);替诺福韦一水合物;9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物);替诺福韦单水合物;9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(含水);(R)-(((1-(6-氨基-9H-嘌呤-9-基)丙烷-2-基)氧基)甲基)磷酸 水合物;替诺福韦一水化合物 |
英文名称 | 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate |
英文同义词 | 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate;Unii-99yxe507il;Tenofovir Monohydrate;Tenofovir (15 mg);Tenofovir (hydrate);[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid monohydrate;PMPA Monohydrate;(R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid hydrate |
CAS号 | 206184-49-8 |
分子式 | C9H16N5O5P |
分子量 | 305.23 |
EINECS号 | 808-956-8 |
相关类别 | 医药中间体;泰诺福韦中间体;对照品-杂质对照品;泰诺福韦系列;医药原料;ALIMTA;对照品 |
Mol文件 | 206184-49-8.mol |
结构式 |
9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物) 性质
熔点 | 270-274oC |
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储存条件 | 2-8°C |
溶解度 | 可溶于酸性水溶液(少许)、DMSO(少许) |
形态 | 固体 |
颜色 | 白色至类白色 |
稳定性 | 吸湿性 |
Tenofovir shows cytotoxic effects on cell viability in HK-2 cells, with IC 50 values of 9.21 and 2.77 μM at 48 and 72 h in MTT assay, respectively. Tenofovir diminishes ATP levels in HK-2 cells. Tenofovir (3.0 to 28.8 μM) increases oxidative stress and protein carbonylation in HK-2 cells. Furthermore, Tenofovir induces apoptosis in HK-2 cells, and that apoptosis is induced via mitochondrial damage. Tenofovir and M48U1 formulated in 0.25% HEC each inhibits the replication of both R5-tropic HIV-1 BaL and X4-tropic HIV-1 IIIb in activated PBMCs, and inhibits several laboratory strains and patient-derived HIV-1 isolates. The combined formulation of M48U1 and tenofovir in 0.25% HEC exhibits synergistic antiretroviral activity against infection with R5-tropic HIV-1 BaL , and is not toxic to PBMCs.
Tenofovir Disoproxil Fumarate (20, 50, 140, or 300 mg/kg) administered to BLT mice, shows dose dependent activity during vaginal HIV challenge in BLT humanized mice. Tenofovir Disoproxil Fumarate (50, 140, 300 mg/kg) significantly reduces HIV transmission in BLT mice. Tenofovir Disoproxil Fumarate (0.5, 1.5, or 5.0 mg/kg/day, p.o.) induces a dose-dependent decline in serum viremia in woodchucks chronically infected with WHV. Tenofovir Disoproxil Fumarate administration is safe and effective in the woodchuck model of chronic HBV infection.
安全信息
海关编码 | 2933599550 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-13910A | 9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物) Tenofovir hydrate | 206184-49-8 | 5mg | 465元 |
2024/08/19 | HY-13910A | 9-[(R)-2-(磷酰甲氧基)丙基]腺嘌呤(一水物) Tenofovir hydrate | 206184-49-8 | 10 mM * 1 mLin DMSO | 512元 |