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| | 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Basic information |
| Product Name: | 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate | | Synonyms: | 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate;Unii-99yxe507il;Tenofovir Monohydrate;Tenofovir (15 mg);Tenofovir (hydrate);[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid monohydrate;PMPA Monohydrate;(R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid hydrate | | CAS: | 206184-49-8 | | MF: | C9H16N5O5P | | MW: | 305.23 | | EINECS: | 808-956-8 | | Product Categories: | ALIMTA | | Mol File: | 206184-49-8.mol | ![9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Structure](CAS/GIF/206184-49-8.gif) |
| | 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Chemical Properties |
| Melting point | 270-274oC | | storage temp. | 2-8°C | | solubility | Aqueous Acid (Slightly), DMSO (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| | 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Usage And Synthesis |
| Chemical Properties | WHITE POWDER SOLID | | Uses | antineoplastic, thymidylate synthase inhibitor | | Uses | Tenofovir Monohydrate is an HIV-1 RT inhibitor and antiretroviral drug. | | Definition | ChEBI: A hydrate that is the monohydrate form of anhydrous tenovir. | | General Description | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Tenofovir is a nucleotide analog reverse transcriptase inhibitor, and is widely used as an antiretroviral agent, for the treatment of HIV infection. | | Biological Activity | tenofovir hydrate is an inhibitor of reverse transcriptase used for the treatment of the human immunodeficiency virus 1(hiv-1) and hepatitis b [1].tenofovir hydrate is an antiviral pro-drug and the class of nucleoside reverse transcriptase inhibitor. in addition, tenofovir hydrate has been reported to have a dependent relation between intracellular the drug concentrations and prevent function of hiv-1infection with ec50 values of 29 fmol/106, 40 fmol/106 , 77 fmol/106 and 411 fmol/106 cells for inoculum size 1, 5, 20 and 100 respectively. and the ec90 values of tenofovir hydrate are 267 fmol/106, 348 fmol/106, 640 fmol/106 and 2866 fmol/106 cells for virus inoculums size 1, 5, 20 and 100, respectively [1]. | | references | [1] duwal s1, schütte c, von kleist m.pharmacokinetics and pharmacodynamics of the reverse transcriptase inhibitor tenofovir and prophylactic efficacy against hiv-1 infection. plos one. 2012;7(7):e40382. doi: 10.1371/journal.pone.0040382. epub 2012 jul 11. |
| | 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Preparation Products And Raw materials |
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