| Company Name: |
Shanghai Macklin Biochemical Co.,Ltd.
|
| Tel: |
15221275939 15221275939 |
| Email: |
shenlinxing@macklin.cn |
| Products Intro: |
Product Name:ICRF-193
CAS:21416-88-6
Purity:98% Package:1mg；5mg
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:ICRF-193
CAS:21416-88-6
Purity:>=95% Package:1mg, 5mg Remarks:I4659
|
| Company Name: |
Hubei Changrun Biomedical Technology Co., Ltd.
|
| Tel: |
027-63496417 13007129042 |
| Email: |
3294393103@qq.com |
| Products Intro: |
Product Name:2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, (R*,S*)-;2,6-Piperazinedione
CAS:21416-88-6
Purity:99% Package:1g;10g;20g
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:ICRF-193
CAS:21416-88-6
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
HEPARIN, SODIUM, LOW MOLECULAR WEIGHT manufacturers
- ICRF-193
-
- $2520.00
-
2026-07-15
- CAS:21416-88-6
- Purity:
- Supply Ability: 10g
|
| | HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Basic information |
| Product Name: | HEPARIN, SODIUM, LOW MOLECULAR WEIGHT | | Synonyms: | 2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, (R*,S*)-;2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, rel-;2,6-Piperazinedione, 4,4'-(1,2-dimethylethylene)di-, meso-;Brn 3981691;meso-2,3-Bis(3,5-dioxopiperazin-1-yl)butane;meso-2,3-Bis(3,5-dioxopiperazine-1-yl)butane;2,6-Piperazinedione, 4,4'-[(1R,2S)-1,2-dimethyl-1,2-ethanediyl]bis-, rel-;ICRF-193 apoptosis inducer, arabinosidase substrate | | CAS: | 21416-88-6 | | MF: | C12H18N4O4 | | MW: | 282.3 | | EINECS: | | | Product Categories: | | | Mol File: | 21416-88-6.mol |  |
| | HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Chemical Properties |
| Boiling point | 526.733±50.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.308 | | storage temp. | -20°C | | solubility | DMSO: soluble4mg/mL | | form | Solid | | pka | 10.699±0.20(predicted) | | color | White to off-white | | biological source | synthetic (organic) | | InChI | 1S/C12H18N4O4/c1-7(15-3-9(17)13-10(18)4-15)8(2)16-5-11(19)14-12(20)6-16/h7-8H,3-6H2,1-2H3,(H,13,17,18)(H,14,19,20)/t7-,8+ | | InChIKey | OBYGAPWKTPDTAS-OCAPTIKFSA-N | | SMILES | C[C@@H]([C@@H](C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2 |
| Hazard Codes | Xn | | Risk Statements | 22-43 | | Safety Statements | 36/37 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | TL6380200 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Skin Sens. 1 |
| | HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Usage And Synthesis |
| Uses | ICRF-193 has been used as a topoisomerase II (TOP2) inhibitor to treat mouse oocytes to investigate the role of TOP2 in meiosis. | | Definition | ChEBI: ICRF-193 is an N-alkylpiperazine that is butane which is substituted by a 3,5-dioxopiperazin-1-yl group at positions 2 and 3. The meso isomer. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an apoptosis inducer and an antineoplastic agent. | | General Description | ICRF-193 is a bisdiopiperazine derivative. It inhibits topoisomerase II by forming a non-cleavablecomplex. | | Biochem/physiol Actions | ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation. Induces apoptosis in several cell lines including K562 and Molt-4 cells., ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α, and may in addition cause DNA strand breaks. |
| | HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Preparation Products And Raw materials |
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