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HOLO-TRANSFERRIN

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Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
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Products Intro: Product Name:HOLO-TRANSFERRIN
CAS:11096-37-0
Purity:99% Package:25KG;5KG;1KG
Company Name: career henan chemical co
Tel: +86-0371-86658258
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Products Intro: Product Name:HOLO-TRANSFERRIN
CAS:11096-37-0
Purity:99% Package:1KG;1USD
Company Name: Hubei Jusheng Technology Co.,Ltd.
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Products Intro: Product Name:HOLO-TRANSFERRIN
CAS:11096-37-0
Purity:0.99 Package:5KG;1KG
Company Name: Chongqing Chemdad Co., Ltd
Tel: +8613650506873
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Products Intro: Product Name:HOLO-TRANSFERRIN
CAS:11096-37-0
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: Zhengzhou Alfa Chemical Co.,Ltd
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Products Intro: CAS:11096-37-0
Purity:97% Package:1g/25g/100g/500g/1kg/bulkpackage

HOLO-TRANSFERRIN manufacturers

  • HOLO-TRANSFERRIN
  • $1.00 / 1KG
  • 2019-07-14
  • CAS:11096-37-0
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 25kg
HOLO-TRANSFERRIN Basic information
Product Name:HOLO-TRANSFERRIN
Synonyms:HUMAN TRANSFERRIN;HUMAN TRASFERRIN;HUMAN SEROTRANSFERRIN;HUMAN APO-TRANSFERRIN;HUMAN HOLO-TRANSFERRIN;HOLO-TRANSFERRIN;HOLO-TRANSFERRIN BOVINE;HOLO-TRANSFERRIN HUMAN
CAS:11096-37-0
MF:C16H22N6O4
MW:362.38368
EINECS:234-318-8
Product Categories:proteins;Apo-Transferrin;Plasma&Blood Proteins;Plasma, Blood, and Related Proteins and Reagents
Mol File:11096-37-0.mol
HOLO-TRANSFERRIN Structure
HOLO-TRANSFERRIN Chemical Properties
storage temp. 2-8°C
solubility H2O: 50 mg/mL
form powder
Water Solubility Soluble in water (50 mg/ml).
CAS DataBase Reference11096-37-0
EPA Substance Registry SystemTransferrin (11096-37-0)
Safety Information
Hazard Codes B,Xi
Risk Statements 36/37/38
Safety Statements 26-37/39
WGK Germany 3
21
TSCA Yes
MSDS Information
ProviderLanguage
SigmaAldrich English
HOLO-TRANSFERRIN Usage And Synthesis
DescriptionHolo-transferrin is the transferrin of the holo iron. It is a kind of iron-binding blood plasmaglycoproteins that is capable of regulating the level of free iron (Fe) in biological fluids. It is responsible for iron transportation in vertebrate serum and donating irons to cells through interaction with the CD71 membrane receptor. Transferrin is crucial for proliferating cells as a growth factor to initiate and maintain the DNA synthesis. It can also act as a cytokine. It is mainly synthesized in liver inside the human body. It is responsible to deliver iron from duodenum and white blood cells macrophages to all the other tissues, and is a key protein to maintain in vivo iron homeostasis. Increased plasma transferrin level is related to diseases such as iron deficiency anemia while decrease plasma transferrin is related to iron overload diseases and protein malnutrition.
UsesTransferrin (Holo) is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. It is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. It can be used with a wide range of cells types. It is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media. It has been used for study in treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.
Uses
All cells require iron for the proper uptake of oxygen from their environment. Transferrin, a protein isolated from serum, causes the uptake and transport of iron from culture medium to the cells. This allows proper oxygen uptake and also stimulates growth-related enzyme activity. Iron-saturated transferrin (holo transferrin) is continually recycled after releasing iron and becomes iron-deficient transferrin (apo-transferrin). Choosing which form to use depends upon the culture conditions. In media such as Dulbecco′s Modified Eagle′s Medium/Ham′s Nutrient Mixture F12 (DMEM/F12) that contain high levels of iron salt, using apo-transferrin is preferred.
Uses
Transferrin is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. Transferrin is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. Human holo-transferrin is a high affinity transferrin that can be used with a wide range of cells types. Human holo-transferrin is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media.
General Description
Transferrin is an 80 kDa serum glycoprotein, which has an half-life of 8 to 10 days. The gene is located on human chromosome 3q22.1. Transferrin is expressed in hepatocytes.
Pharmaceutical ApplicationsTransferrins are a group of proteins that are abundant in blood and their primary role is to transport Fe3+, as free Fe3+ would be toxic to most organisms. Transferrin consists of a single polypeptide chain independently binding a maximum of two Fe3+ ions. Fe3+ is bound in a hexa-coordinated high-spin complex within the protein. The metal is coordinated by the N atom from the imidazole residue, two deprotonated phenol groups, a carboxylate and a carbonato ligand.
Biochem/physiol ActionsStudies have shown that co-treatment of breast cancer cells with holo-transferrin, which increases iron levels within cells and derivatives of artemisinin results in increased cell death.
Purification MethodsThis transferrin is purified by affinity chromatography on phenyl-boronate agarose followed by DEAE-Sephacel chromatography. The product is free from haemopexin. [Cook et al. Anal Biochem 149 349 1985, Aisen & Listowsky Ann Rev Biochem 49 357 1980.]
Referenceshttps://en.wikipedia.org/wiki/Transferrin
http://www.prospecbio.com/Holo_Transferrin_Human_11_121/
HOLO-TRANSFERRIN Preparation Products And Raw materials
Tag:HOLO-TRANSFERRIN(11096-37-0) Related Product Information
Ferritin INVERTOSE Lactoferrin Transglutaminase TRANSFERRIN (APO)--N/H TRANSFERRIN (HOLO),HUMAN SER Bovine Holo Transferrin tranferrin ELSA diagnostic kit COBALT ETHYLENE DIAMINE CHLORIDE Ferric acetylacetonate Tris(2,4-pentanedionato)chroMiuM(III) 2,4-PENTANEDIONE, SILVER DERIVATIVE N-BUTYLISOCYANIDE COBALT(II) ACETYLACETONATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Aluminum acetylacetonate Tosylmethyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)