1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮
| 中文名称 | 1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮 |
|---|---|
| 中文同义词 | 1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮;1H-[1,2,4]恶二唑并[4,3-A]喹恶啉-1-酮;1H-[1,2,4]恶二唑并[4,3-A]喹喔啉-1-酮;1H-[1,2,4]噁二唑并[4,3-A]喹喔啉-1-酮;1H- [1,2,4]恶二唑[4,3-A]喹喔啉-1-酮;H-[1,2,4]恶二唑并[4,3-A]喹喔啉-1-酮 |
| 英文名称 | ODQ |
| 英文同义词 | ODQ;2-OXA-3,5,9B-TRIAZA-CYCLOPENTA[A]NAPHTHALENE-1-ONE;1H-[1,2,4]OXADIAZOLE[4,3-A]QUINOXALIN-1-ONE;1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE;ODQ,98%;ODQ1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one;1H-[1,2,4]Oxadiazolo[4,3-A]quinoxalin-1-one (9ci);1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE[ODQ] |
| CAS号 | 41443-28-1 |
| 分子式 | C9H5N3O2 |
| 分子量 | 187.15 |
| EINECS号 | |
| 相关类别 | 合成;生化试剂;Cyclic Nucleotide related;Amines;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Signalling;Pharmaceuticals;Antineoplastic |
| Mol文件 | 41443-28-1.mol |
| 结构式 | ![1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮 结构式](CAS/GIF/41443-28-1.gif) |
1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮 性质
| 熔点 | 160-170 °C |
|---|---|
| 沸点 | 321.89°C (rough estimate) |
| 密度 | 1.3753 (rough estimate) |
| 折射率 | 1.6500 (estimate) |
| RTECS号 | RO0913150 |
| 储存条件 | 2-8°C |
| 溶解度 | 乙醇：1.2 mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 0.94±0.20(Predicted) |
| 颜色 | 淡黄色低 |
| 稳定性 | DMSO中的溶液可在-20°下稳定储存3个月。 |
| CAS 数据库 | 41443-28-1(CAS DataBase Reference) |
ODQ (1H-ODQ) 是一种有效的和选择性的 soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) 的抑制剂，可增强顺铂在人类间皮瘤细胞中的促凋亡作用。
| Target | Value |
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sGC
() |
At 30 and 50 μM, ODQ causes significant induction of apoptosis in the NCI-H2452 cells, elevating apoptotic levels by 12 fold and 15 fold, respectively. At 10μM, a concentration below the threshold for induction of apoptosis by ODQ, ODQ in combination with Cisplatin enhanced (in fact, doubled) the pro-apoptotic effects of Cisplatin at 1 μM.
ODQ (2 mg/kg; i.p.) reduces the multiple organ injury and dysfunction caused by wall fragments of Gram-positive or Gram-negative bacteria in the anesthetized rat.
| Animal Model: | Anesthetized, male Wistar rats |
| Dosage: | 2 mg/kg |
| Administration: | I.p. |
| Result: | Attenuated the renal dysfunction, lung injury, and hepatocellular injury caused by lipoteichoic acid/peptidoglycan or lipopolysaccharide. |
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | C32880 | 1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮 10MG ODQ, 98% | 41443-28-1 | 10mg | 1826元 |
| 2024/04/30 | C32880 | 1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮 10MG ODQ, 98% | 41443-28-1 | 50mg | 7226元 |