FEXARAMINE
中文名称 | FEXARAMINE |
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中文同义词 | 3-[3-[(环己基羰基)[[4'-(二甲基氨基)[1,1'-联苯]-4-基]甲基]氨基]苯基]-2-丙烯酸甲酯;3-[3-[(环己基羰基)[[4\'-(二甲基氨基)[1,1\'-联苯]-4-基]甲基]氨基]苯基]-2-丙烯酸甲酯, >98%;(E)-3-(3-(N-((4'-(二甲基氨基)-[1,1'-联苯]-4-基)甲基)环己烷甲酰胺基)苯基)丙烯酸甲酯;(E)-3-(3-(N-((4'-(二甲基氨基)-[1,1'-联苯]-4-基)甲基)环己烷甲酰胺基)苯基)丙烯酸甲酯;FEXARAMINE,受体(FXR)激动剂 |
英文名称 | Fexaramine |
英文同义词 | Fexaramine;3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoicacidmethylester;2-Propenoic acid, 3-[3-[(cyclohexylcarbonyl)[[4'-(diMethylaMino)[1,1'-biphenyl]-4-yl]Methyl]aMino]phenyl]-, Methyl ester;(E)-methyl 3-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;(2E,4Z)-5-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecarboxamido)phenyl)-4-(methoxycarbonyl)penta-2,4-dienoic acid;3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-pr;3-[3-[(Cyclohexylcarbonyl)[[4\'-(dimethylamino)[1,1\'-biphenyl]-4-yl]methyl]amino]phenyl]-2-Propenoic acid methyl ester, >98%;CS-1691 |
CAS号 | 574013-66-4 |
分子式 | C32H36N2O3 |
分子量 | 496.64 |
EINECS号 | |
相关类别 | 小分子抑制剂;小分子抑制剂,天然产物;标准品;Inhibitors |
Mol文件 | 574013-66-4.mol |
结构式 |
FEXARAMINE 性质
沸点 | 677.7±55.0 °C(Predicted) |
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密度 | 1.158±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMSO:50 mg/mL(100.68 mM;需要超声波) |
酸度系数(pKa) | 4.95±0.24(Predicted) |
形态 | 粉末 |
颜色 | 白色至米色 |
Target | Value |
FXR
() | 25 nM(EC50) |
Bile acid treatment is performed in HuTu-80 cells with Fexaramine (5, 25, and 50 μM) for 24 h. Fexaramine (50 μM) increases small heterodimer partner (SHP) transcript levels by 2.1-fold. The cells are treated with various concentrations of Fexaramine, and the endogenous secretin transcript levels are significantly reduced (33% in 50 μM Fexaramine). Fexaramine treatment also significantly suppresses secretin promoter activity by 32%.
Fexaramine treatment of DIO mice produces a striking metabolic profile that includes reduced weight gain, decreased inflammation, browning of WAT and increased insulin sensitization.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-10912 | Fexaramine | 5 mg | 750元 | |
2024/08/19 | HY-10912 | FEXARAMINE Fexaramine | 574013-66-4 | 10mg | 1200元 |