ChemicalBook > Product Catalog >API >Nervous system drugs >Antiepileptic and anticonvulsant >5,5-Diphenylhydantoin


5,5-Diphenylhydantoin Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:5,5-Diphenylhydantoin
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:57-41-0
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Products Intro: Product Name:5,5-Diphenylhydantoin
Company Name: PI & PI BIOTECH INC.
Tel: 020-81716320
Products Intro: Product Name:Phenytoin
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Remarks:5,5-Diphenylimidazolidine-2,4-dione.
Company Name: Wuhan FengyaoTonghui Chemical Products Co., Ltd.  Gold
Tel: 027-87466205 15377573527
Products Intro: Product Name:5,5-Diphenylhydantoin
Purity:98% Package:1kg
5,5-Diphenylhydantoin Basic information
Product Name:5,5-Diphenylhydantoin
Product Categories:API's;Aromatics;Heterocycles;API intermediate
Mol File:57-41-0.mol
5,5-Diphenylhydantoin Structure
5,5-Diphenylhydantoin Chemical Properties
Melting point 293-295 °C(lit.)
Boiling point 395.45°C (rough estimate)
density 1.1562 (rough estimate)
refractive index 1.5906 (estimate)
Fp 11 °C
storage temp. 2-8°C
solubility DMSO: soluble
pkapKa 8.43(H2O,t =25,I=0.025) (Uncertain)
form Powder
color White to almost white
Water Solubility <0.01 g/100 mL at 19 ºC
Merck 14,7322
BRN 384532
Stability:Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference57-41-0(CAS DataBase Reference)
NIST Chemistry Reference5,5-Diphenylhydantoin(57-41-0)
EPA Substance Registry System2,4-Imidazolidinedione, 5,5-diphenyl-(57-41-0)
Safety Information
Hazard Codes T,Xn,F
Risk Statements 45-61-22-63-40-39/23/24/25-23/24/25-11-20/21/22
Safety Statements 53-45-36/37-16-7
WGK Germany 3
RTECS MU1050000
HazardClass 6.1(b)
PackingGroup II
HS Code 29332100
Hazardous Substances Data57-41-0(Hazardous Substances Data)
ToxicityLD50 in mice (mg/kg): 92 i.v.; 110 s.c. (Stille, Brunckow)
MSDS Information
5,5-Diphenyl-2,4-imidazolidinedione English
ACROS English
SigmaAldrich English
ALFA English
5,5-Diphenylhydantoin Usage And Synthesis
Chemical Propertieswhite crystals or powder
Chemical PropertiesPhenytoin is a crystalline compound
UsesReduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.
UsesA sodium channel protein inhibitor
DefinitionChEBI: A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5.
Brand nameAnticonvulsant. Dilantin (Pfizer) [Name previously used: Diphenylhydantoin.].
General DescriptionFine white or almost white crystalline powder. Odorless or almost odorless. Tasteless.
Air & Water ReactionsInsoluble in water.
Reactivity Profile5,5-Diphenylhydantoin is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). 5,5-Diphenylhydantoin is incompatible with strong oxidizers and strong bases.
Fire HazardFlash point data for 5,5-Diphenylhydantoin are not available; however, 5,5-Diphenylhydantoin is probably combustible.
Safety ProfileConfirmed carcinogen producing lymphoma, Hodgkin's disease, tumors of the skin and appendages. Experimental carcinogenic and tumorigenic data. A human poison by ingestion. Poison experimentally by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by an unspecified route. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: dermatitis, change in motor activity (specific assay), ataxia (loss of muscle coordmation), degenerative brain changes, encephalitis, hallucinations, dtstorted perceptions, irritabihty, and jaundice. Human teratogenic effects by ingestion: developmental abnormalities of the central nervous system, carlovascular (circulatory) system, musculoskeletal system, craniofacial area, skin and skin appendages, eye, ear, other developmental abnormalities. Effects on newborn include abnormal growth statistics (e.g., reduced weight gain), physical abnormakties, other postnatal measures or effects, and delayed effects. Human mutation data reported. A drug for the treatment of grand mal and psychomotor seizures. When heated to decomposition it emits toxic fumes of NOx
Potential ExposurePhenytoin is an amide pharmaceutical used in the treatment of grand mal epilepsy, Parkinson’s syndrome; and in veterinary medicine. Human exposure to phenytoin occurs principally during its use as a drug. Figures on the number of patients using phenytoin are not available, but phenytoin is given to a major segment of those individuals with epilepsy. The oral dose rate is initially 100 mg given 3 times per day and can gradually increase by 100 mg every 24 weeks until the desired therapeutic response is obtained. The intravenous dose is 200350 mg/day.
First aidSkin Contact: Flood all areas of body that have contacted the substance with water. Don’t wait to remove contaminated clothing; do it under the water stream. Use soap to help assure removal. Isolate contaminated clothing when removed to prevent contact by others. Eye Contact: Remove any contact lenses at once. Flush eyes well with copious quantities of water or normal saline for at least 2030 minutes. Seek medical attention. Inhalation: Leave contaminated area immediately; breathe fresh air. Proper respiratory protection must be supplied to any rescuers. If coughing, difficult breathing or any other symptoms develop, seek medical attention at once, even if symptoms develop many hours after exposure. Ingestion: If convulsions are not present, give a glass or two of water or milk to dilute the substance. Assure that the person’s airway is unobstructed and contact a hospital or poison center immediately for advice on whether or not to induce vomiting.
ShippingUN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification MethodsCrystallise the hydantoin from EtOH. [Beilstein 24 III/IV 1748.]
IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Similar organic amides react with azo and diazo compounds, releasing toxic gases. Contact with reducing agents can release flammable gases. Amides are very weak bases but they can react as acids, forming salts. Mixing amides with dehydrating agents such as phosphorus pentoxide or thionyl chloride generates the corresponding nitrile.
5,5-Diphenylhydantoin Preparation Products And Raw materials
Preparation Products2,4,6-Trifluorophenol
Raw materialsBenzaldehyde
Tag:5,5-Diphenylhydantoin(57-41-0) Related Product Information
Caffeine Citrate 5,5-DIPHENYLHYDANTOIN-D5 98 ATOM % D,5,5-Diphenylhydantoin-d5 Imirestat Ropitoin 1-Phenylsulfonyl-5,5-diphenylhydantoin 5,5-DIPHENYLHYDANTOIN-3-BUTYRIC ACID 5-(4-HYDROXYPHENYL)-5-PHENYL-D5-HYDANTOIN-15N2 5,5-DIPHENYLHYDANTOIN (2-13C)(15N2),5,5-DIPHENYLHYDANTOIN (2-13C,1,3-15N2) 2,4-Imidazolidinedione, 5,5-diphenyl-3-ethyl-1-(2-hydroxy-3-(1-piperid inyl)propyl)-, monohydrochloride 1-(4-(2-Hydroxyethyl)-1-piperazine-2-propanolo)-3-ethyl-5,5-diphenylhy dantoin 2HCl hydrate 3-amino-5,5-diphenylhydantoi 5,5-Diphenylhydantoin 5,5-DIPHENYLHYDANTOIN SODIUM SALT 98+%,5,5-DIPHENYLHYDANTOIN SODIUM SALT,5,5-DIPHENYLHYDANTOIN SODIUM,DIPHENYLHYDANTOIN SODIUM SALT,SODIUM 5,5-DIPHENYLHYDANTOIN,SODIUM DIPHENYLHYDANTOIN BCDMH Iprodione Biphenyl 1,3-Dibromo-5,5-dimethylhydantoin Fosphenytoin sodium