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Diethyl chlorophosphate

Diethyl chlorophosphate Basic information
Product Name:Diethyl chlorophosphate
Synonyms:Diethoxy chlorophosphate;Phosphoric acid chloride diethyl ester;Chloridophosphoric acid diethyl;Chloridophosphoric acid diethyl ester;Chlorophosphonic acid diethyl;Chlorophosphonic acid diethyl ester;Chlorophosphonic acid O,O-diethyl ester;Diethyl phosphoric chloride
CAS:814-49-3
MF:C4H10ClO3P
MW:172.55
EINECS:212-396-4
Product Categories:Phosphorus compounds;Pharmaceutical Intermediates;Miscellaneous Reagents
Mol File:814-49-3.mol
Diethyl chlorophosphate Structure
Diethyl chlorophosphate Chemical Properties
Melting point 95-96 °C
Boiling point 60 °C2 mm Hg(lit.)
density 1.194 g/mL at 25 °C(lit.)
vapor density 5.94 (vs air)
vapor pressure 0.1 mm Hg ( 25 °C)
refractive index n20/D 1.416(lit.)
Fp 142 °F
storage temp. 2-8°C
solubility Chloroform (Sparingly)
form Liquid
color Clear colorless to light yellow
Water Solubility Soluble in alcohol and chloroform. Slightly soluble in water.
Sensitive Moisture Sensitive
BRN 471433
Stability:Hygroscopic, Moisture Sensitive
InChIKeyLGTLXDJOAJDFLR-UHFFFAOYSA-N
LogP0.61
CAS DataBase Reference814-49-3(CAS DataBase Reference)
NIST Chemistry ReferencePhosphorochloridic acid, diethyl ester(814-49-3)
EPA Substance Registry SystemDiethyl chlorophosphate (814-49-3)
Safety Information
Hazard Codes T+
Risk Statements 23-27/28-33-26/27/28-34
Safety Statements 26-36/37/39-45-38-28A-7/9-28
RIDADR UN 2927 6.1/PG 1
WGK Germany 3
RTECS TD1400000
10-19-21
TSCA Yes
HazardClass 6.1(a)
PackingGroup II
HS Code 29199000
Hazardous Substances Data814-49-3(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Phosphorochloridic acid diethyl ester English
SigmaAldrich English
ACROS English
Diethyl chlorophosphate Usage And Synthesis
DescriptionDiethyl chlorophosphate is a combustible,clear liquid with an unpleasant odor. Molecularweight=172.76; Boiling point=60℃ at 2.0 mmHg; 81℃at 6.0 mmHg. Freezing/Melting point=0℃. HazardIdentification (based on NFPA-704 M Rating System):Health 4, Flammability 2, Reactivity 2 . Reacts withwater.
Chemical Propertiesclear colorless to light yellow liquid
UsesA phosphorous halide used for biochemical research. Also used as an intermediate in organic synthesis.
General DescriptionClear liquid. Diethyl chlorophosphate is used as an intermediate in organic synthesis.
Reactivity ProfileOrganophosphates, such as Diethyl chlorophosphate, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Health HazardDiethyl chlorophosphate is a cholinesterase inhibitor. It has high oral and very high dermal toxicity. It is a skin irritant. It is also toxic by inhalation.
Fire HazardEmits very toxic fumes of chloride and phosphorus oxides when heated to decomposition.
Safety ProfileDeadly poison by skin contact. Poison by ingestion. A cholinesterase inhibitor. See also PARATHION. Trace HCl catalyzes a hazardous reaction during the preparation of diethyl phosphate from diethyl chlorophosphate. When heated to decomposition it emits very toxic fumes of Cl and POx.
Potential ExposureThis material may be used as an intermediate in the manufacture of pesticides and chemical warfare agents.
First aidIf this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Speed in removing material from skinis of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If thischemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, includingresuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give conscious victims water or milk.Promote excretion by administering saline cathartic or sorbitol. Do not make an unconscious person vomit.
storageColor Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area away from oxidizers and reducing agents.Where possible, automatically pump liquid from drums orother storage containers to process containers.
ShippingOrganophosphorus compound, toxic n.o.s.requires a label of “POISONOUS/TOXIC MATERIALS.”These materials fall in Hazard Class 6.1 and Packing GroupII.
IncompatibilitiesContact with oxidizers may cause therelease of phosphorous oxides. Contact with strong reducingagents, such as hydrides, may cause the formation of flammable and toxic phosphine gas. Strong oxidizers, bases.
Tag:Diethyl chlorophosphate(814-49-3) Related Product Information
Diphenyl chlorophosphate Mefenpyr-diethyl Diethylphosphorodithioate Ethyl dichlorophosphate Diethyl methylphosphonate DIETHYL PHOSPHATE Diethyl carbonate Diethyl cyanomethylphosphonate Triethyl phosphite DIETHYL ETHYLPHOSPHONATE Diethyl phthalate Diethyl cyanophosphonate Clodronate disodium Triethyl phosphate Diethyl phosphite Methyl acrylate Diethyl malonate Tris(trimethylsilyl)phosphate