Canagliflozin heMihydrate

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Company Name: Anqing Chico Pharmaceutical Co., Ltd.
Tel: 15380796838
Email: chloewu@chicopharm.cn
Products Intro: Product Name:Canagliflozin heMihydrate
CAS:928672-86-0
Purity:99% Package:10g;100g;1kg; 25kg or More
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Canagliflozin heMihydrate
CAS:928672-86-0
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:928672-86-0
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
Email: fandachem@gmail.com
Products Intro: Product Name:Canagliflozin heMihydrate
CAS:928672-86-0
Purity:as in COA Package:as customers' requirements Remarks:Canagliflozin heMihydrate
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;product@chemlin.com.cn
Email: product@chemlin.com.cn
Products Intro: CAS:928672-86-0
Purity:99% Package:g-Kg Remarks:White powder

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Canagliflozin heMihydrate Basic information
Product Name:Canagliflozin heMihydrate
Synonyms:Cagliflozin heMihydrate;Canagliflozin hydrate (2:1);Canagliflozin heMihydrate;D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, hydrate (2:1);Canagliflozin heMihydrates;(2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Hemihydrate;(1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol hydrate (2:1);Cageline
CAS:928672-86-0
MF:2(C24H25FO5S).H2O
MW:0
EINECS:
Product Categories:Canagliflozin
Mol File:Mol File
Canagliflozin heMihydrate Structure
Canagliflozin heMihydrate Chemical Properties
Safety Information
MSDS Information
Canagliflozin heMihydrate Usage And Synthesis
DescriptionCanagliflozin, an orally active and selective sodium–glucose cotransporter 2 (SGLT2) inhibitor, was co-developed by Mitsubishi Tanabe Pharma and Johnson & Johnson (J&J) for the treatment of type 2 diabetes mellitus (T2DM) and obesity. The drug was approved in March by the U.S. FDA and launched in April 2013 in the U.S. SGLT2 is involved in the glucose re-absorption pathway in the kidney, and its inhibition increases urinary glucose excretion, and reduces plasma glucose and HbA1c levels. In addition, canagliflozin is safe in combination with other commonly used antidiabetic agents and has a significant effect on body weight reduction. A recently published process patent from ScinoPharm Taiwan describes the synthesis of canagliflozin.
Chemical SynthesisSynthesis of the aglycone region of canagliflozin was described in a separate patent by first condensing commercially available 5- bromo-2-methylbenzoyl chloride (14) and 2-(4-fluorophenyl)- thiophene (15) under Friedel–Crafts acylation conditions to give ketone 16 in 69% yield as a crystalline solid. Ketone 16 was then reduced with triethylsilyl hydride in the presence of BF3Et2O at low temperature to give aglycone bromide 17 in 70% yield. The precursor for the glycoside moiety, commercially available glycoside triol 18, was selectively treated with t-butyldiphenylsilyl chloride (TBDPSCl) in THF in the presence of imidazole to give the bis-silyl ether 19 in 81% yield. Next, a unique, stereospecific b-C-arylglucosidation was developed to secure the union of the aglyone- and glycoside-containing portions of canagliflozin. Bromide 17 was subjected to magnesium powder under standard Grignard conditions prior to treatment with AlCl3 in THF in situ. This resulting mixture was then exposed to a solution of compound 19 in PhOMe which had been pre-treated with n-BuLi, and the entire mixture was then warmed to 150 ℃ for 5 h to ultimately give the b-anomer 20 in 56% yield. Finally, removal of the silyl groups within 20 with tetrabutyl ammonium fluoride (TBAF) in THF delivered canagliflozin hydrate (III) in 73% yield.

Canagliflozin heMihydrate Preparation Products And Raw materials
Tag:Canagliflozin heMihydrate(928672-86-0) Related Product Information
(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one 4-Iodo-1-chloro-2-(4-ethoxybenzyl)benzene 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE 5-Bromo-2-methylbenzoic acid D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, tetraacetate, (1S)- (9CI) 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 5-Bromo-2-methylbenzoyl chloride 5-Iodo-2-methylbenzoic acid LIPOPHILIC SEPHADEX 2-(4-FLUOROPHENYL)THIOPHENE Canagliflozin Canagliflozin Enantiomer Impurity NA Canagliflozin α Isomer NA BCP19353