UKI-1

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UKI-1 Suppliers list
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 15026964105
Email: 2881489226@qq.com
Company Name: Amadis Chemical Company Limited  
Tel: 571-89925085
Email: sales@amadischem.com
Company Name: Musechem  
Tel: +1-800-259-7612
Email: info@musechem.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com

UKI-1 manufacturers

  • UKI-1
  • UKI-1 pictures
  • $347.00
  • 2026-07-27
  • CAS:220355-63-5
  • Purity:
  • Supply Ability: 10g
  • UKI-1
  • UKI-1 pictures
  • $347.00
  • 2026-07-27
  • CAS:220355-63-5
  • Purity:
  • Supply Ability: 10g
  • UKI-1
  • UKI-1 pictures
  • $347.00
  • 2025-07-19
  • CAS:220355-63-5
  • Purity:
  • Supply Ability: 10g
UKI-1 Basic information
Product Name:UKI-1
Synonyms:UKI-1;1-Piperazinecarboxylic acid, 4-[(2S)-3-[3-(aminoiminomethyl)phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-, ethyl ester;UKI-1C;UKI 1,UKI1;Upamostat Impurity 4;ethyl (S)-4-(3-(3-carbamimidoylphenyl)-2-((2,4,6-triisopropylphenyl)sulfonamido)propanoyl)piperazine-1-carboxylate
CAS:220355-63-5
MF:C32H47N5O5S
MW:613.81
EINECS:
Product Categories:
Mol File:220355-63-5.mol
UKI-1 Structure
UKI-1 Chemical Properties
Boiling point 745.5±70.0 °C(Predicted)
density 1.23±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 28 mg/mL (45.62 mM)
form Solid
pka9.76±0.50(Predicted)
color White to off-white
Safety Information
MSDS Information
UKI-1 Usage And Synthesis
UsesUKI-1 (WX-UK1) is a potent urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 0.41 μM. UKI-1 is also a low molecular weight serine protease inhibitor. UKI-1 is a potent antimetastatic agent and inhibits the invasive capacity of carcinoma cells[1][2].
in vivo

UKI-1 (WX-UK1) treatment has antimetastatic activities that significantly reduces the number of metastatic lesions and tumor growth in metastasizing rat pancreatic and mammary adenocarcinoma tumor models[1].

References[1] Ertongur S et al. Inhibition of the invasion capacity of carcinoma cells by WX-UK1, a novel synthetic inhibitor of the urokinase-type plasminogen activator system. Int J Cancer. 2004 Jul 20;110(6):815-24. DOI:10.1002/ijc.20192
[2] Ewa Zeslawska et al. Crystals of the urokinase type plasminogen activator variant βc-uPA in complex with small molecule inhibitors open the way towards structure-based drug design. J Mol Biol. 2000 Aug 11;301(2):465-75. DOI:10.1006/jmbi.2000.3966
UKI-1 Preparation Products And Raw materials
Tag:UKI-1(220355-63-5) Related Product Information
WX-671/Mesupron UKI-1 1-Piperazinecarboxylic acid, 4-[(2S)-3-[3-(aminoiminomethyl)phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-, ethyl ester, hydrochloride (1:1) WX-UK1 Upamostat Serpin E1 Protein, Rat (HEK293, His)