ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Leucine derivatives >(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE

(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE

(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE Suppliers list
Company Name: Alpha Biopharmaceuticals Co., Ltd
Tel: 0086-411-39042497
Email: sales@alphabiopharm.com
Products Intro: Product Name:E-64
CAS:66701-25-5
Purity:>98.5% Package:5g;25g;100g;250g;1kg;bulk Remarks:B0185
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: Product Name:E-64
CAS:66701-25-5
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Email: linda@hubeijusheng.com
Products Intro: Product Name:(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE
CAS:66701-25-5
Purity:0.99 Package:5KG;1KG
Company Name: BOC Sciences
Tel: 1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:E-64
CAS:66701-25-5
Purity:>98%
Company Name: Target Molecule Corp
Tel: 781-999-5354 18019718960
Email: marketing@targetmol.com
Products Intro: Product Name:E-64;E64;E 64;Proteinase inhibitor E 64
CAS:66701-25-5
Purity:99.84% Package:5 mg;10 mg;25 mg;50 mg;100 mg;200 mg;1 mL * 10 mM (in DMSO);2 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE Basic information
Product Name:(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE
Synonyms:(2S,3S)-3-(((S)-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylic acid;(2S,3S)-3-(((S)-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carb;oxiranecarboxylicacid,3-(((1-(((4-((aminoiminomethyl)amino)butyl)amino)carbon;proteinaseinhibitore64;thiolproteaseinhibitor;TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-*(4-GU ANIDINO)BUT;(2S, 3S)-TRANS-EPOXY SUCCINYL-L-LEUCYLAMIDO-(4-GUANIDINO) BUTANE;L-TRANS-3-CARBOXYOXIRAN-2-CARBONYL-L-LEUCYLAGMATINE
CAS:66701-25-5
MF:C15H27N5O5
MW:357.41
EINECS:613-978-4
Product Categories:Pepetides;ProteaseInhibitors;peptides;inhibitor;Inhibitors
Mol File:66701-25-5.mol
(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE Structure
(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE Chemical Properties
density 1.44±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility H2O: 20 mg/mL, clear, colorless
pka3.16±0.40(Predicted)
form White solid
Water Solubility Soluble in DMSO (25mg/ml), or water (20mg/ml)
Sensitive Light Sensitive
BRN 1405664
InChIKeyLTLYEAJONXGNFG-DCAQKATOSA-N
CAS DataBase Reference66701-25-5(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
RTECS RR0390000
10
HS Code 29252900
MSDS Information
ProviderLanguage
SigmaAldrich English
(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE Usage And Synthesis
UsesIt is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained
General Description
E-64 is a cysteine protease inhibitor that was isolated from the mold Aspergillus japonicus TPR-64. E-64 is also known as N-[N-(L-3-trans-carboxyoxiran-2-carbonyl)-L-leucyl]-agmatine. E-64 effectively inhibits various cysteine proteases, in particular:
  • cathepsin K
  • cathepsin L
  • cathepsin S
E-64 also acts against other enzymes, such as:
  • calpain
  • cathepsin B
  • cathepsin H
  • papain
HazardA reproductive hazard.
Biochem/physiol ActionsE-64 is an irreversible, potent, and highly selective cysteine protease inhibitor. E-64 does not react with the functional thiol group of non-protease enzymes, such as L-lactate dehydrogenase or creatine kinase. E-64 will not inhibit serine proteases (except trypsin) like other cysteine protease inhibitors, leupeptin and antipain. The trans-epoxysuccinyl group (active moiety) of E-64 irreversibly binds to an active thiol group in many cysteine proteases, such as papain, actinidase, and cathepsins B, H, and L to form a thioether linkage. E-64 is a very useful cysteine protease inhibitor for use in in vivo studies because it has a specific inhibition, it is permeable in cells and tissues and has low toxicity.
(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE Preparation Products And Raw materials
Tag:(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE(66701-25-5) Related Product Information
3,4-DICHLOROISOCOUMARIN ACTINONIN glutamyl-glycyl-arginine chloromethyl ketone Bestatin Trametinib Z-VAD-FMK Pepstatin Everolimus 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE 2-Hydroxy-4-amino butanoic acid (2-amino-2-oxoethoxy)acetic acid (R)-(-)-AMINO-3-HYDROXYBUTANOIC ACID GLYCIDAMIDE 2(2-HYDROXYETHOXY)ACETAMIDE (2-AMINO-ETHOXY)-ACETIC ACID TRANS-2,3-EPOXYBUTANE EP 459