兰雪醌
中文名称 | 兰雪醌 |
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中文同义词 | 兰雪醌\2,3-二氯-1,4-二氨基蒽醌;石苁溶萘醌;白花丹醌(白花丹素);白花丹精;白花丹醌;矶松素;矾松素;石苁蓉萘醌 |
英文名称 | PLUMBAGIN |
英文同义词 | plumbagone;1,4-Dihydro-1,4-dioxo-5-hydroxy-2-methylnaphthalene;Plumbagin (natural);PLUMBAGIN PRACTICAL GRADE;Plumbagin, 99+%;PLUMBAGIN(RG);1,4-NAPHTHALENEDIONE,5-HYDROXY-2-METHYL;PLANT STEROLS KIT |
CAS号 | 481-42-5 |
分子式 | C11H8O3 |
分子量 | 188.18 |
EINECS号 | 207-569-6 |
相关类别 | 小分子抑制剂,天然产物;小分子抑制剂;标准品;植物提取物;蒽醌;Anthraquinones, Hydroquinones and Quinones;Inhibitors;chem-chemical |
Mol文件 | 481-42-5.mol |
结构式 |
兰雪醌 性质
熔点 | 76-78 °C(lit.) |
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沸点 | 283.17°C (rough estimate) |
密度 | 1.354 |
折射率 | 1.6310 (estimate) |
储存条件 | -20°C |
溶解度 | 在热甲醇中有非常微弱的浑浊 |
酸度系数(pKa) | 6.70±0.20(Predicted) |
形态 | 晶体或结晶粉末 |
颜色 | 橙色 |
Merck | 7538 |
稳定性 | 吸湿性 |
LogP | 2.450 (est) |
EPA化学物质信息 | 1,4-Naphthalenedione, 5-hydroxy-2-methyl- (481-42-5) |
Plumbagin (0, 5, 10, and 15 μM) induces apoptosis of prostate cancer cell lines, such as DU145, CWR22rv1 and LNCaP, in a dose-dependent manner.
Plumbagin (5, 20 μM) obviously inhibits the invasion of PC3, DU145, and CWR22rv1 cells.
Apoptosis Analysis
Cell Line: | DU145, CWR22rv1, LNCaP and RWPE-1 cells |
Concentration: | 0, 5, 10, and 15 μM |
Incubation Time: | 24 hours |
Result: | Dose-dependently induced apoptosis of DU145, CWR22rv1 and LNCaP, but showed no effect on RWPE-1 cells at up to 20 μM. |
Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits the growth of tumor in male athymic nude mice.
Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits expression of PKCε, suppresses JAK-2 and Stat3 phosphorylation, and activates Stat3, PCNA, VEGF and MMP-9 in mice.
Animal Model: | Male athymic nude mice bearing DU145 cells |
Dosage: | 2 mg/kg |
Administration: | I.P. after 3 days post cell implantation, five days a week. |
Result: | Delayed tumor growth by 3 weeks, and reduced tumor weight and volume in mice. |
安全信息
危险品标志 | T |
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危险类别码 | 25-34-36/37/38 |
安全说明 | 22-26-36/37/39-45-37/39-28A |
危险品运输编号 | UN 2923 8/PG 2 |
WGK Germany | 3 |
RTECS号 | QL8500000 |
Hazard Note | Toxic |
危险等级 | 6.1(a) |
包装类别 | II |
海关编码 | 29146990 |
毒性 | LD50 i.p. in mice: ~0.015 g/kg (Debray) |
提供商 | 语言 |
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英文
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