益母草碱单盐酸盐
中文名称 | 益母草碱单盐酸盐 |
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中文同义词 | 益母草碱单盐酸盐;盐酸益母草碱(益母草碱盐酸盐);4-胍基丁基 4-羟基-3,5-二甲氧基苯甲酸酯 盐酸盐;益母草盐酸盐;盐酸益母草碱,10 MM DMSO 溶液 |
英文名称 | 4-Guanidinobutyl 4-hydroxy-3,5-diMethoxybenzoate hydrochloride |
英文同义词 | 4-Hydroxy-3,5-dimethoxybenzoic acid 4-[(aminoiminomethyl)amino]butyl ester monohydrochloride;Leonurin monohydrochloride;4-Guanidinobutyl 4-hydroxy-3,5-diMethoxybenzoate hydrochloride;SCM-198 hydrochloride;SCM-198 HCl;Leonurine hydrochloride-RM;Leonurine Hydrochloride(P);Leonurine hydrochloride, 10 mM in DMSO |
CAS号 | 24735-18-0 |
分子式 | C14H22ClN3O5 |
分子量 | 347.79458 |
EINECS号 | |
相关类别 | 标准品 |
Mol文件 | 24735-18-0.mol |
结构式 | ![]() |
益母草碱单盐酸盐 性质
熔点 | 194℃ |
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储存条件 | Sealed in dry,Room Temperature |
溶解度 | 可溶于DMSO(轻微)、甲醇(非常轻微,加热) |
形态 | 固体 |
颜色 | 白色至类白色 |
Leonurine (0, 5, 10, 20, 40, 80 µM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24 h. Leonurine hydrochloride (125, 250, 500 μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20 µM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner.
Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20 mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2025/02/05 | S9047 | 益母草碱单盐酸盐 Leonurine Hydrochloride | 24735-18-0 | 5mg | 1204.75元 |
2023/03/20 | S9047 | 益母草碱单盐酸盐 Leonurine Hydrochloride | 24735-18-0 | 25mg | 3849.55元 |