阿雷地平
| 中文名称 | 阿雷地平 |
|---|---|
| 中文同义词 | 2,6-二甲基-4-(2-硝基苯基)-1,4-二氢-3,5-吡啶二羧酸甲基2-氧丙基酯;阿雷地平;2,6-二甲基-4-(2-硝基苯基)-1,4-二氢-3,5-吡啶二羧酸 3-甲基 2-氧代丙基酯;3-甲基 5-(2-氧丙基)2,6-二甲基-4-(2-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸;阿雷地平标准品;阿雷地平对照品 |
| 英文名称 | ARANIDIPINE |
| 英文同义词 | ARANIDIPINE;2，6-Dimethyl-4-(2-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 2-oxopropyl ester;MPC-1304;Sapresta;1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(2-oxopropyl) ester;Asanidipine;3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-methyl 5-(2-oxopropyl)ester;3-Methyl 5-(2-oxopropyl) 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| CAS号 | 86780-90-7 |
| 分子式 | C19H20N2O7 |
| 分子量 | 388.37 |
| EINECS号 | |
| 相关类别 | 抗心绞痛药;心脑血管药物;药物;对照品;原料药 |
| Mol文件 | 86780-90-7.mol |
| 结构式 |  |
阿雷地平 性质
| 熔点 | 155° |
|---|---|
| 沸点 | 530.0±50.0 °C(Predicted) |
| 密度 | 1.284±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：125 mg/mL（321.86 mM） |
| 酸度系数(pKa) | 2.56±0.70(Predicted) |
Ca 2+ Channel
Aranidipine (MPC-1304) is a new Ca 2+ channel antagonist in spontaneously hypertensive rats. Following oral administration of Aranidipine at doses of 3 and 10 mg/kg to spontaneously hypertensive rats (SHR), there are significant decreases in B max values for specific [ 3 H](+)-PN 200-110 binding to myocardial membranes compared to the control values. The B max values at 1 h (3 mg/kg), 1 and 6 h (10 mg/kg) are significantly decreased (47.7, 48.9 and 25.8%, respectively) compared to the control values. The effect is greatest at 1 h and decreases with time. The B max values at 6 h (3 mg/kg) and 12 or 24 h (10 mg/kg) after the oral administration of Aranidipine are not significantly different from the control values, suggesting the disappearance of the effect of Aranidipine. The K d values for myocardial [ 3 H](+)-PN 200-110 binding are unaltered by oral administration of Aranidipine.
安全信息
| 毒性 | LD50 in male, female mice, rats (mg/kg): 143, 193, 1982, 1459 orally; LD50 in male, female mice (mg/kg): 7.3, 9.1 i.p. (Nakano) |
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-U00212 | 阿雷地平 Aranidipine | 86780-90-7 | 5mg | 600元 |
| 2024/01/25 | HY-U00212 | 阿雷地平 Aranidipine | 86780-90-7 | 10mg | 900元 |