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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
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Product Name:4,9-Anhydrotetrodotoxin
CAS:13072-89-4
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
BOC Sciences
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info@bocsci.com |
| Products Intro: |
Product Name:4,9-Anhydrotetrodotoxin
CAS:13072-89-4
Purity:≥98% by HPLC Remarks:4,9-Anhydrotetrodotoxin is a derivative of tetrodotoxin, which is a potent neurotoxin and can be isolated from pufferfish. It is also a selective and potent Nav1.6 channel blocker with IC50 value of 7
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
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Product Name:4,9-Anhydrotetrodotoxin
CAS:13072-89-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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marketing@energy-chemical.com |
| Products Intro: |
Product Name:4,9-Anhydro-tetrodotoxin
CAS:13072-89-4
Purity:NULL Package:100g;250g;500g Remarks:NULL
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| | anhydrotetrodotoxin Basic information |
| Product Name: | anhydrotetrodotoxin | | Synonyms: | anhydrotetrodotoxin;(8S)-4,9-Dideoxy-4β,9β-epoxytetrodotoxin;4,9-Anhydrotetrodotoxin;4,9-Dideoxy-4β,9β-epoxytetrodotoxin;(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol;6,10-Epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol, 2-amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-, (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-;9-anhydro-TTX;4,9Anhydrotetrodotoxin,4,9 Anhydrotetrodotoxin | | CAS: | 13072-89-4 | | MF: | C11H15N3O7 | | MW: | 301.25 | | EINECS: | | | Product Categories: | | | Mol File: | 13072-89-4.mol |  |
| | anhydrotetrodotoxin Chemical Properties |
| storage temp. | -20° | | solubility | Soluble in Ethanol (up to 10 mg/ml). | | form | A solid or film | | color | Colorless | | Water Solubility | Soluble to 1 mg/ml in water | | Stability: | Stable for 2 years from date of purchase as supplied. Protect from exposure to light or moisture. Solutions are not stable. Solutions must be prepared fresh and used within 1 working day. |
| | anhydrotetrodotoxin Usage And Synthesis |
| Description | 4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 μM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively. | | storage | Store at -20°C | | References | 1) Rosker?et al. (2007),?The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel; Am.J.Physiol.Cell Physiol.,?293?C783.
2) Denomme?et al.?(2020),??The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6;?Neurosci. Lett.?724?134853 |
| | anhydrotetrodotoxin Preparation Products And Raw materials |
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