ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Esters >Methyl ester compound >Methyl 4-tert-butylbenzoate

Methyl 4-tert-butylbenzoate

Methyl 4-tert-butylbenzoate Suppliers list
Tel: 13812269233
Products Intro: Product Name:Methyl 4-tert-Butyl Benzoate (MPTBBA)
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Methyl 4-tert-butylbenzoate
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:26537-19-9
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Products Intro: Product Name:Methyl 4-Tert-Butylbenzoate
Purity:98% Package:200kg;USD
Company Name: career henan chemical co
Tel: +86-371-86658258
Products Intro: Product Name:Methyl 4-tert-butylbenzoate
Purity:99% Package:1KG;1USD

Lastest Price from Methyl 4-tert-butylbenzoate manufacturers

Methyl 4-tert-butylbenzoate Basic information
Overview Synthesis method The effect of nitric acid concentration, reaction temperature and reaction time on the synthesis of products Application
Product Name:Methyl 4-tert-butylbenzoate
Synonyms:Methyl 4-tert-butylbenzoate (MPTBBA);Para tert-butylbenzoic acid ester;N-[5-tert-butyl-4-[[6-hydroxy-4-oxo-2-(2-phenylethyl)-2-propan-2-yl-3H-pyran-5-yl]thio]-2-methylphenyl]methanesulfonamide;4-hydroxyphenylglyoxylicacidsodiumsalt;Benzoic acid, 4-(1,1-dimethylethyl)-, methyl ester;Benzoic acid, p-tert-butyl-, methyl ester;butylbenzoicacidmethylester;Methyl p-tert-butylbenzoate
Product Categories:Aromatic Esters;Acids & Esters;OPLAS;C12 to C63;Carbonyl Compounds;Esters;Building Blocks;C12 to C63;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
Mol File:26537-19-9.mol
Methyl 4-tert-butylbenzoate Structure
Methyl 4-tert-butylbenzoate Chemical Properties
Boiling point 122-124 °C9 mm Hg(lit.)
density 0.995 g/mL at 25 °C(lit.)
refractive index n20/D 1.51(lit.)
Fp >230 °F
form Liquid
color Clear colorless to yellow
Specific Gravity0.995
CAS DataBase Reference26537-19-9(CAS DataBase Reference)
NIST Chemistry Reference4-Tert-butylbenzoic acid methyl ester(26537-19-9)
EPA Substance Registry SystemBenzoic acid, 4-(1,1-dimethylethyl)-, methyl ester (26537-19-9)
Safety Information
Safety Statements 24/25
WGK Germany 3
HS Code 29163990
MSDS Information
Methyl 4-tert-butylbenzoate English
ACROS English
SigmaAldrich English
ALFA English
Methyl 4-tert-butylbenzoate Usage And Synthesis
OverviewMethyl 4-tert-butylbenzoate appears as white crystalline powder, being slightly soluble in water with the water solubility of 0.006g/100ml Water at 20 ° C. It can be miscible in ethanol, ether and other organic solvents with the organic toluene solubility of 9.0%, being an important organic synthesis intermediates. It is an important additive during the production of PVC heat stabilizer, PP nucleating agent, sunscreen and scaling powder. As the alkyd resin modifier, it can improve the resin luster, color, and speed up the resin drying time and improve the chemical resistance of the performance. The ammonium salt can improve the performance of friction parts and prevent rust, thus can be used as the additives of cutting oil and lubricants. Its sodium salt, barium salt, zinc salt can be used as polymer stabilizer and nucleating agent.
Synthesis methodThe synthesis method of P-tert-butyl benzoic acid includes:
The oxidation method of liquid phase solvent, take acetic acid as solvent, lead acetate as oxidant and synthesize p-tert-butyl benzoic acid at low temperature.
Liquid non-solvent oxidation method: there is no need of any solvent; take cobalt acetate and sodium bromide as a catalyst and apply air oxidation at 170e temperature to obtain the final products.
High temperature gas phase oxidation method, in the presence of catalyst, high temperature lead to vaporization and oxidation of p-tert-butyl toluene to generate p-tert-butyl benzoic acid.
Recently, we found that there is no need of any catalyst if using cheap nitric acid as the oxidant for oxidation of p-tert-butyl toluene to get the crude t-butyl benzoic acid, followed by being dissolved with sodium hydroxide to remove organic impurities and insoluble matter, and then being acidified to obtain pure p-tert-butyl benzoic acid. This method has good selectivity and low energy consumption, and can avoid the shortcomings of air oxidation method such as low oxidation conversion rate, thus having great practical value.
Preparation of crude p-tert-butyl benzoic acid:
To a 500 mL autoclave, add 26 mL (0.2 mol, 29.6 g) of p-tert-butyltoluene, 26 mL 68% nitric acid (0.4 mol, 37 g) and 2.5 mL of water. The reaction stirrer was started and the temperature was raised to 180e. The reaction lasted for 8 hour followed by cooling with cool water. Open the reactor with most of the solid being deposited on the bottom of the reactor and attached to the reactor cooling tube in a small amount. The solid was collected, filtered and dried to give 34.5 g with a yield of 95.5%.
The purification of P-tert-butylbenzoic acid
Weigh 10 g of sodium hydroxide and add 90 mL of water to prepare a 10% sodium hydroxide solution. Add the above solid into it. After being sufficiently dissolved, the filtrate was adjusted to pH 3 with hydrochloric acid, and a large amount of crystals would be precipitated at this time. The solution was allowed to stand for 33.4 g with a yield of 98.2%. The product was analyzed by infrared spectroscopy, displaying the characteristic peaks of p-tert-butylbenzoic acid. The content was 98.4% by HPLC analysis with a melting point of 164~166e (literature values 164~165e).
The effect of nitric acid concentration, reaction temperature and reaction time on the synthesis of products
  • Effect of nitric acid concentration on the product
A series of nitric acid concentration experiments were carried out at two temperatures. The reaction temperature of curve 1 was 160e and the reaction temperature of curve 2 was 180e. The product content was obtained by liquid chromatography (HPLC) normalization. It can be seen that with the decrease of nitric acid concentration, the content of p-tert-butylbenzoic acid increased, the concentration of nitric acid decreased to about 10%. When the temperature reached 180e, the content reaches the highest value. When the concentration of nitric acid was higher than 50%, we couldn’t obtain the desired product. In addition, in this experiment, it could also be seen the impact of temperature on the product. The content in the series of high temperature was significantly higher than that of the low temperature series.
  • The effect of reaction temperature on the product
Considering the effect of reaction temperature, we selected the concentration of nitric acid at 10%. The effect of temperature on the product was that the reactant could not get the desired product at the reflux temperature. With the increase of temperature, the product content exhibits an increasing trend. At 170e, the content reaches the highest value with further increasing the temperature having almost no effect on the content.
  • The effect of reaction time on the reaction
A large number of experiments have found that the reaction time only affects the reaction conversion rate, without affecting product selectivity. That is, it does not affect the content of the product and only affects the yield of the product. In the experiment, it can be clearly seen of that the reaction time is not enough when the reactor floating above a layer of liquid organic matter, the analysis is the raw material of tert-butyl toluene.
From the analysis of the data, we can see that the reaction temperature has the greatest influence on the yield. Considering various factors, we selected the reaction conditions as: the temperature: 180e, reaction time: 8h and nitric acid concentration: 10%. According to this condition, the content of p-tert-butylbenzoic acid was 98.4% and the yield was 95.5%.
ApplicationImportant intermediates for organic synthesis.
Methyl 4-tert-butylbenzoate Preparation Products And Raw materials
Tag:Methyl 4-tert-butylbenzoate(26537-19-9) Related Product Information
4-tert-Butylcatechol 4-tert-Butylcyclohexyl acetate 4-tert-Butylbenzoyl chloride (2,6-DICHLORO-4-PYRIDYL)METHYL 4-(TERT-BUTYL)BENZOATE 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-5-YL 4-(TERT-BUTYL)BENZOATE 4,4'-(Hexafluoroisopropylidene)diphthalic anhydride 4-TERT-BUTYLBENZOIC ACID VINYL ESTER ETHYL 4-TERT-BUTYLBENZOATE 4-tert-Butylphthalic anhydride Paraquat dichloride 4-tert-Butylaniline tert-Butyl methyl ether 4-tert-Butylbenzoic acid tert-Butylhydroquinone Basic Violet 1 Methyl acrylate 4-tert-Butylbenzenesulfonyl chloride Acetonitrile