BOC-11-AMINOUNDECANOIC ACID manufacturers
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| | BOC-11-AMINOUNDECANOIC ACID Basic information |
| Product Name: | BOC-11-AMINOUNDECANOIC ACID | | Synonyms: | BOC-11-AMINOUNDECANOIC ACID;BOC-11-AMINOUNDECYLIC ACID;BOC-11-AUN-OH;BOC-NH-(CH2)10-COOH;11-(BOC-AMINO)-UNDECANOIC ACID;T-BUTOXYCARBONYL-11-AMINOUNDECANOIC ACID;T-BUTOXYCARBONYL-11-AMINOUNDECYLIC ACID;N-TERT-BUTYLOXYCARBONYL-11-AMINO-UNDECANOIC ACID | | CAS: | 10436-25-6 | | MF: | C16H31NO4 | | MW: | 301.42 | | EINECS: | | | Product Categories: | Amino Acids | | Mol File: | 10436-25-6.mol |  |
| | BOC-11-AMINOUNDECANOIC ACID Chemical Properties |
| Melting point | 67-68 °C | | Boiling point | 441.9±18.0 °C(Predicted) | | density | 1.006±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 4.78±0.10(Predicted) | | color | White to Almost white | | BRN | 1975656 | | CAS DataBase Reference | 10436-25-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 2924.19.8000 | | HazardClass | IRRITANT |
| | BOC-11-AMINOUNDECANOIC ACID Usage And Synthesis |
| Description | Boc-11-aminoundecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine. | | Chemical Properties | White powder | | Uses | Boc-11-aminoundecanoic acid is an Alkyl/ether-based?PROTAC linker?can be used in the synthesis of MS432 (HY-130602)[1]. | | reaction suitability | reaction type: Boc solid-phase peptide synthesis | | IC 50 | Alkyl/ether | | References | [1] Wei J, et al.Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.J Med Chem. 2019 Dec 12;62(23):10897-10911. DOI:10.1021/acs.jmedchem.9b01528 |
| | BOC-11-AMINOUNDECANOIC ACID Preparation Products And Raw materials |
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