七叶皂苷D
中文名称 | 七叶皂苷D |
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中文同义词 | 七叶皂苷D;七叶皂苷 IIB |
英文名称 | ESCIN IIB |
英文同义词 | AESCIN IIB;ESCIN IIB;06035642G6;b-D-Glucopyranosiduronic acid, (3b,4b,16a,21b,22a)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-ylO-b-D-glucopyranosyl-(14)-O-[b-D-xylopyranosyl-(12)]-;β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→4)-O-[β-D-xylopyranosyl-(1→2)]-;EscinID |
CAS号 | 158800-83-0 |
分子式 | C54H84O23 |
分子量 | 1101.23 |
EINECS号 | |
相关类别 | 标准品;对照品;中药对照品;植物提取物;标准品 -中药标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
Mol文件 | 158800-83-0.mol |
结构式 |
七叶皂苷D 性质
沸点 | 1111.9±65.0 °C(Predicted) |
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密度 | 1.45±0.1 g/cm3 (20 ºC 760 Torr) |
酸度系数(pKa) | 2.63±0.70(Predicted) |
Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibit the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest.
Escin IIb (10-50 mg/kg; p.o.) potently inhibits ethanol-induced gastric mucosal lesions.
Animal Model: | Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats) |
Dosage: | P.o. |
Administration: | 10-50 mg/kg |
Result: | Showed a potent protective effect against ethanol-induced gastric lesions in rats. |