地榆皂苷Ⅱ
| 中文名称 | 地榆皂苷Ⅱ |
|---|---|
| 中文同义词 | 地榆皂苷 II;地榆皂苷II(标准品);地榆甙II;地榆皂苷LL;地榆皂苷II对照品,;地榆皂苷II、地榆苷Ⅱ;坡模酸-3-O-Α-L-吡喃阿拉伯糖苷;地榆皂苷Ⅱ |
| 英文名称 | Ziyuglycoside II |
| 英文同义词 | Ziyuglycoside II;(3beta)-3-(alpha-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid;Zigu-glucoside II;Gouguside 1;(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid;Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, (3β)-;Ziyuglycoside;(3β)-3-(α-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oicaci |
| CAS号 | 35286-59-0 |
| 分子式 | C35H56O8 |
| 分子量 | 604.83 |
| EINECS号 | 233-305-4 |
| 相关类别 | 中药对照品;标准品;植物提取物;对照品;植提标准品;分析试剂标准品;标准品-中药标准品;标准品-对照品;对照品-中药对照品;三萜;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品 -中药标准品;标准品，对照品 |
| Mol文件 | 35286-59-0.mol |
| 结构式 |  |
地榆皂苷Ⅱ 性质
| 熔点 | 260-263℃ |
|---|---|
| 沸点 | 716.2±60.0 °C(Predicted) |
| 密度 | 1.25 |
| 储存条件 | -20°C, protect from light |
| 溶解度 | 溶于DMSO和甲醇； |
| 酸度系数(pKa) | 4.47±0.70(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
| 水溶解性 | insoluble in water |
| InChIKey | MFIXLWYJTVEVGO-VHOGPVSJNA-N |
| SMILES | C[C@]12CC[C@H](O[C@]3([H])OC[C@H](O)[C@H](O)[C@H]3O)C(C)(C)[C@]1([H])CC[C@]4(C)[C@]2([H])CC=C5[C@@]4(C)CC[C@]6(C(O)=O)[C@@]5([H])[C@@](O)(C)[C@H](C)CC6 |
Ziyuglycoside II 是从 Sanguisorba officinalis L. 中提取的三萜皂苷化合物。Ziyuglycoside II 诱导活性氧 (ROS) 产生和凋亡 (apoptosis)。 具有抗炎和抗癌作用。
药理药效:具有一定的酪氨酸酶抑制作用，保肝利胆效果。
Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC
50
of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively.
Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h.
Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells.
Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent.
Cell Viability Assay
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 10, 20, 30, 40, 50, 60 μM |
| Incubation Time: | 24 hours and 48 hours |
| Result: | The IC 50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively. |
Cell Cycle Analysis
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 5, 10, 25 μM |
| Incubation Time: | 24 hours |
| Result: | Induced G0/G1 and S phase arrest. |
Apoptosis Analysis
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 5, 10, 25 μM |
| Incubation Time: | 24 hours |
| Result: | The apoptotic rate was significantly increased in comparison to that of the control. |
Western Blot Analysis
| Cell Line: | MDA-MB-435 cells |
| Concentration: | 5, 10, 25 μM |
| Incubation Time: | 24 hours |
| Result: | Treatment resulted in increased expressions of both p53 and p21. |
化学性质
白色结晶体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于地榆。用途
地榆皂苷Ⅱ具有收缩血管，止血，抗真菌的作用。用途
用于含量测定/鉴定/药理实验等。药理药效:具有一定的酪氨酸酶抑制作用，保肝利胆效果。
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-N0332 | 地榆皂苷Ⅱ Ziyuglycoside II | 35286-59-0 | 5mg | 550元 |
| 2025/12/22 | HY-N0332 | 地榆皂苷Ⅱ Ziyuglycoside II | 35286-59-0 | 10mg | 950元 |