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| 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Basic information |
| 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Chemical Properties |
Melting point | 56-58 °C(lit.) | Boiling point | 65-66 °C8 mm Hg(lit.) | density | 1.1850 (estimate) | Fp | 65-66°C/8mm | storage temp. | Inert atmosphere,Room Temperature | pka | 10.17±0.18(Predicted) | form | powder to crystal | color | White to Gray to Brown | Water Solubility | Soluble 0.68 G/L | BRN | 2359087 | CAS DataBase Reference | 394-32-1(CAS DataBase Reference) | NIST Chemistry Reference | 5-Fluoro-2-hydroxyacetophenone(394-32-1) |
| 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Usage And Synthesis |
Chemical Properties | light yellow to beige-brown crystals | Uses | 5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:
- 1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one
- 3-hydroxy and 3-methoxyflavones
- 3-hydroxy and 3-methoxy 2-styrylchromones
| Definition | ChEBI: 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone. | Preparation | Preparation by Fries rearrangement of 4-fluorophenyl acetate with aluminium chloride without solvent between 115° and 150° (88–89%). | General Description |
5-fluoro-2-hydroxy acetophenone, also known as 2-ethanoyl-4-fluorophenol or 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone, is a kind of important medicine intermediate, can be used as multiple beta-blockers synthetic intermediate, has vast market prospect.
| Synthesis |
The preparation method of 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone under following steps: Performing double esterification on amino groups and phenolic hydroxy in one step by taking amino-phenol as a raw material. Performing Fries rearrangement under the condition of aluminum chloride/sodium chloride. Heating a hydrolyzate after completing fluorine diazotization to obtain finished 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone.
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| 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Preparation Products And Raw materials |
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