| | LORMETAZEPAM Basic information |
| Product Name: | LORMETAZEPAM | | Synonyms: | 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-;2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-;2h-1,4-benzodiazepin-2-one,1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1;2h-1,4-benzodiazepin-2-one,7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy;7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1h-1,4-benzodiaze;7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one;7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one | | CAS: | 848-75-9 | | MF: | C16H12Cl2N2O2 | | MW: | 335.18 | | EINECS: | 212-700-5 | | Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 848-75-9.mol |  |
| | LORMETAZEPAM Chemical Properties |
| Melting point | 163-168°C | | Boiling point | 575.8±50.0 °C(Predicted) | | density | 1.4463 (rough estimate) | | refractive index | 1.6100 (estimate) | | Fp | 9℃ | | storage temp. | Controlled Substance, -20°C Freezer | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 11.60±0.40(Predicted) | | color | Pale Yellow to Pale Green |
| | LORMETAZEPAM Usage And Synthesis |
| Chemical Properties | Pale Green Solid | | Originator | Loramet ,Wyeth, W. Germany,1980 | | Uses | An analog of Lorazepam (L469850). Sedative, hypnotic.
Controlled substance (depressant). | | Definition | ChEBI: Lormetazepam is a 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorophenyl group at the 5-position and a chloro substituent at the 7-position. It has a role as a sedative. It is a 1,4-benzodiazepinone and an organochlorine compound. | | Manufacturing Process | To a suspension of 3.4 g of 3-acetoxy-7-chloro-1,3-dihydro-5-(ochlorophenyl)-2H-1,4-benzodiazepin-2-one in 80 ml of alcohol was added 6 ml of 4 N sodium hydroxide. After complete solution had taken place a solid precipitated that redissolved upon the addition of 80 ml of water. The solution was acidified with acetic acid to give white crystals. After recrystallization from alcohol the compound melted at 192°C to 194°C. | | Therapeutic Function | Hypnotic |
| | LORMETAZEPAM Preparation Products And Raw materials |
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