- 2-Amino-4-bromopyridine
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- $0.00 / 25kg
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2025-12-01
- CAS:84249-14-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
- 4-Bromopyridin-2-amine
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- $15.00 / 1KG
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2021-07-13
- CAS:84249-14-9
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 2-Amino-4-bromopyridine Basic information |
| | 2-Amino-4-bromopyridine Chemical Properties |
| Melting point | 142-146 °C | | Boiling point | 268.2±20.0 °C(Predicted) | | density | 1.710±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 5.72±0.11(Predicted) | | form | Solid | | color | Off-White to Beige | | InChI | InChI=1S/C5H5BrN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8) | | InChIKey | BAQKUNMKVAPWGU-UHFFFAOYSA-N | | SMILES | C1(N)=NC=CC(Br)=C1 | | CAS DataBase Reference | 84249-14-9(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-36-22 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2 |
| | 2-Amino-4-bromopyridine Usage And Synthesis |
| Chemical Properties | Off-White to Beige Solid | | Uses | 2-Amino-4-bromopyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | | Synthesis | General procedure for the synthesis of 2-amino-4-bromopyridine from 2-Boc amine-4-bromopyridine: 2-Boc amine-4-bromopyridine (200 mg, 0.73 mmol) was suspended in water (1 mL) and hydrobromic acid (1 mL, 48 wt% aqueous solution) was added. The reaction mixture was stirred at room temperature for 16 h before being poured into aqueous sodium bicarbonate (25 mL) and extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, dried over magnesium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (pure ethyl acetate as eluent) to give 2-amino-4-bromopyridine. Yield: 73 mg (58%). LC/MS retention time: 0.69 min. m/z by mass spectrometry (electrospray positive ion mode): 175, 173 [M+H]+. | | References | [1] Patent: WO2008/57497, 2008, A2. Location in patent: Page/Page column 301
[2] Patent: WO2007/89669, 2007, A2. Location in patent: Page/Page column 212-213
[3] Patent: WO2008/57469, 2008, A1. Location in patent: Page/Page column 301
[4] Patent: WO2008/57468, 2008, A1. Location in patent: Page/Page column 301
[5] Australian Journal of Chemistry, 1982, vol. 35, # 10, p. 2025 - 2034 |
| | 2-Amino-4-bromopyridine Preparation Products And Raw materials |
| Raw materials | 4-Amino-2-bromopyridine-->2-Chloro-4-bromopyridine-->4-Bromo-2-pyridinecarboxamide-->TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE-->4-Bromopyridine-2-carboxylic acid-->2,4-Dibromopyridine-->4-Amino-2-picoline-->4-Bromo-2-methylpyridine-->2,4-Dihydroxypyridine-->4-Nitro-2-picoline N-oxide | | Preparation Products | 4-broMo-5-iodopyridin-2-aMine-->7-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine-->4-(7-BROMO-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-2-YL)MORPHOLINE-->[1,2,4]Triazolo[1,5-a]pyridin-7-amine, 2-(3-methoxyphenyl)--->N-(4-broMopyridin-2-yl)-N'-ethylurea |
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