| Company Name: |
Guangzhou PI PI Biotech Inc
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| Tel: |
+86-020-81716320 +86-13602409664 |
| Email: |
Sales@pipitech.com |
| Products Intro: |
Product Name:Bamifylline
CAS:2016-63-9
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:8’-Benzyl-7-(2-[ethyl(2-hydroxyethyl)amino]ethyl)theophylline
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| Company Name: |
Sichuan Guanghan Bio-Tech Co., Ltd
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| Tel: |
+86-28-86127071 |
| Email: |
info@sino-produce.com |
| Products Intro: |
Product Name:BAMIFYLLINE
CAS:2016-63-9
Purity:97.00% Package:100g;500g;1kg;10kg;50kg;100kg;1ton
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| | BAMIFYLLINE Basic information |
| Product Name: | BAMIFYLLINE | | Synonyms: | BAMIFYLLINE;8-BENZYL-7-(2-(HYDROXYETHYL)AMINO)ETHYL)THEOPHYLLINE;8102 CB;8102CB;Bamiphylline;Bax-2739Z;CB-8102;8-benzyl-7-(2-(N-ethyl-2-hydroxyethylamino)ethyl)theophylline | | CAS: | 2016-63-9 | | MF: | C20H27N5O3 | | MW: | 385.46 | | EINECS: | | | Product Categories: | | | Mol File: | 2016-63-9.mol |  |
| | BAMIFYLLINE Chemical Properties |
| Melting point | 80-80.5° | | Boiling point | 619.0±65.0 °C(Predicted) | | density | 1.25 | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | Chloroform (Very Slightly), DMSO (Slightly), Methanol (Slightly) | | pka | 14.73±0.10(Predicted) | | form | Solid | | color | White to Pale Brown | | Stability: | Hygroscopic |
| | BAMIFYLLINE Usage And Synthesis |
| Originator | Bamifylline,ZYF Pharm Chemical | | Uses | Bronchodilator. | | Uses | Bamifylline is a drug of the xanthine chemical class which acts as a selective adenosine A1 receptor antagonist. | | Definition | ChEBI: Bamifylline is an oxopurine. | | Manufacturing Process | A mixture of 100 kg of 8-benzyltheophilline, 36 L of N-ethylethanolamine, 300
L of 1,2-dichlorethane and 71 kg of sodium carbonate was refluxed for 24
hours. Then 36 L of N-ethylethanolamine was added and the reaction mixture
was refluxed. After cooling to the mixture was added the water and
hydrochloric acid. The organic phase was extracted with hydrochloric acid. The
acidic phase was neutralized with sodium carbonate and the 7-(N-ethyl-N-β-
hydroxyethylaminoethyl)-8-benzyltheophilline was extracted with
dichloromethane. The solvent was evaporated and the free base of 7-(N-ethyl-
N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was dissolved in methanol.
Hydrochloride of 7-(N-ethyl-N-β-hydroxyethylaminoethyl)-8-benzyltheophilline
was obtained by addition to the solution the hydrochloric acid; yield 81%,
melting point 185-186°C. | | Therapeutic Function | Bronchodilator, Coronary vasodilator |
| | BAMIFYLLINE Preparation Products And Raw materials |
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