amfenac

amfenac Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:amfenac
CAS:51579-82-9
Purity:99% Package:25KG;5KG;1KG
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:2-(2-Amino-3-benzoylphenyl)acetic acid
CAS:51579-82-9
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-50912
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Amfenac;NSC309467;NSC 309467;NSC-309467
CAS:51579-82-9
Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Products Intro: Product Name:Amfenac
CAS:51579-82-9
Purity:> 95% Remarks:https://www.bocsci.com/product/amfenac-cas-51579-82-9-466443.html
Company Name: SynAsst Chemical.  
Tel: 021-60343070
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Products Intro: Product Name:2-(2-AMino-3-benzoylphenyl)acetic acid
CAS:51579-82-9
Purity:96%Min Package:10g 100g 500g
amfenac Basic information
Product Name:amfenac
Synonyms:2-Amino-3-benzoylbenzeneacetic acid;SOYCMDCMZDHQFP-UHFFFAOYSA-N;Nepafenac Impurity 5(Amfenac);Benzeneacetic acid, 2-amino-3-benzoyl-;Amfenac D5Q: What is Amfenac D5 Q: What is the CAS Number of Amfenac D5 Q: What is the storage condition of Amfenac D5 Q: What are the applications of Amfenac D5
CAS:51579-82-9
MF:C15H13NO3
MW:255.27
EINECS:
Product Categories:
Mol File:51579-82-9.mol
amfenac Structure
amfenac Chemical Properties
Melting point 121-123° (dec)
Boiling point 398.5°C (rough estimate)
density 1.1654 (rough estimate)
refractive index 1.5500 (estimate)
Safety Information
ToxicityLD50 in mice, rats (mg/kg): 615, 311 orally (Sancilio)
MSDS Information
amfenac Usage And Synthesis
OriginatorAmfenac sodium,Yungjin Pharmacetical Co. Ltd.
UsesAnti-inflammatory.
DefinitionChEBI: An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used fo the treatment of pain and inflammation following cataract surgery.
Manufacturing Process7-Benzoylindolin-2-one:
Method A. A mixture of 2.5 g (0.0077 mole) of ethyl 2-acetamido-3- benzoylphenylacetate in 50 ml of 3 N hydrochloric acid was refluxed for one hour. The reaction mixture was filtered and the filtrate was poured into a mixture of ice and water. The precipitate was collected and recrystallized from acetone; yield of 7-benzoylindolin-2-one 1 g (55%); melting point 154°C.
Method B. A solution of 1.3 g (0.0044 mole) of 2-acetamido-3- benzoylphenylacetic acid in 15 ml of 3 N hydrochloric acid and 15 ml of acetic acid was refluxed for three hours. The cooled solution was poured into ice water and the 7-benzoylindolin-2-one which precipitated was collected and dried.
2-Amino-3-benzoylphenylacetic acid:
A mixture of 1.0 g (0.004 mole) of 7-benzoylindolin-2-one was added to 30 ml of 3 N sodium hydroxide and the basic solution was refluxed for 45 min under nitrogen. The mixture was filtered and the filtrate was neutralized with glacial acetic acid. The precipitate was filtered off, washed with water and dried. The 2-amino-3-benzoylbenzeneacetic acid melted at 122°C (dec.). The yield was 0.8 g (72%).
Therapeutic FunctionAntiinflammatory
amfenac Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Sodium hydroxide-->Acetic acid
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