里查酮 A

里查酮 A

中文名称里查酮 A
中文同义词里查酮 A;(S)-5,7-二羟基-2-(4-羟基-2-甲氧基苯基)-8-((R)-5-甲基-2-(丙-1-烯-2-基)己-4- 烯-1-基)苯并二氢吡喃-4-酮;异苦参酮,勒奇黄烷酮A
英文名称(2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2-methoxy-4-hydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one
英文同义词(2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2-methoxy-4-hydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one;Leachianone A;Leachiane A;(S)-5,7-Dihydroxy-2-(4-hydroxy-2-Methoxyphenyl)-8-((R)-5-Methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)chroMan-4-one;2'-methoxy-5,7,4'-trihydroxy-8-lavandulylflavanone;(-)-Vexibidin;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-;(2S)-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one
CAS号97938-31-3
分子式C26H30O6
分子量438.51
EINECS号
相关类别标准品;植物提取物;标准品 -对照药材;黄酮
Mol文件97938-31-3.mol
结构式里查酮 A 结构式

里查酮 A 性质

沸点649.7±55.0 °C(Predicted)
密度1?+-.0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。
形态粉末
酸度系数(pKa)7.67±0.40(Predicted)

里查酮 A 用途与合成方法

Leachianone A 从槐花中分离,具有抗疟疾,抗炎和细胞毒性作用。 Leachianone A 诱导细胞凋亡 (apoptosis)。

Leachianone A (0-20 μg/ml; 24-72 hours) exhibits a marked inhibition on the survival of HepG2 cells time- and dose-dependently manner, IC 50 values are 6.9 μg/ml, 3.4 μg/ml and 2.8 μg/ml in cells with 24-, 48- and 72-hours treatment, respectively. Leachianone A (10-30 μg/ml; 48 hours) indicates that at low concentration of LA (10 μg/ml), a substantial amount of cells is primarily in the early phase of apoptosis, at higher concentrations, induces a shift of the cell population to late apoptotic/ necrotic stage. Leachianone A (10-30 μg/ml; 48 hours) decreases the precursor of caspase-3 in a dose-dependent manner, reduces the protein level of the pro-forms of upstream initiator caspases, caspases-8 and -9, decreases two downstream substrates, namely inhibitor of caspase-activated DNase(ICAD) and poly-ADP-ribose polymerase (PARP) in HepG2 cells.

Cell Viability Assay

Cell Line: HepG2 cells
Concentration: 0 μg/ml, 2 μg/ml, 4 μg/ml, 6 μg/ml, 8 μg/ml, 10 μg/ml, 12 μg/ml, 14 μg/ml, 16 μg/ml, 18 μg/ml, 20 μg/ml
Incubation Time: 24-72 hours
Result: Inhibited HepG2 cells survival.

Apoptosis Analysis

Cell Line: HepG2 cells
Concentration: 48 hours
Incubation Time: 10, 20, and 30 μg/ml
Result: Induced the proportion of annexin V-stained cells in both the early and late apoptotic stage.

Western Blot Analysis

Cell Line: HepG2 cells
Concentration: 48 hours
Incubation Time: 10, 20, and 30 μg/ml
Result: Decreased the protein expression of caspase-3, caspases-8 and -9, reduced ICAD and PARP protein expression.

Leachianone A (intravenously injection; 20 mg/kg, 30 mg/kg; once daily; 30 days) significantly diminishes the tumor volume by 17-54% in LA-treated nude mice, when compared with those solely given the vehicle.

Animal Model: Male nude mice with human hepatoma HepG2 cells
Dosage: 20 mg/kg; 30 mg/kg
Administration: Intravenously injection; 20 mg/kg, 30 mg/kg; once daily; 30 days
Result: Suppressed the tumor growth in vivo.

安全信息

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-N2281里查酮 A
Leachianone A
97938-31-31mg1600元
2024/01/25HY-N2281里查酮 A
Leachianone A
97938-31-35mg3500元

里查酮 A 上下游产品信息

"里查酮 A"相关产品信息
ω-苄基苯乙酮 新橙皮苷二氢查耳酮
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