| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
|
| | 3,4-Dimethoxyphenylboronic acid Basic information |
| Product Name: | 3,4-Dimethoxyphenylboronic acid | | Synonyms: | 3,4-Dimethoxyphenylboronic;3,4-DIMETHOXYPHENYLBORONIC AICD;3,4-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride);3,4-Dimethoxyphenylboronic acid,97%;Boronicacid, (3,4-dimethoxyphenyl)- (9CI);BORONICACID, (3,4-DIMETHOXYPHENYL)- (9CI);;3,4-Dimethoxyphenylboronic acid ,98%;(3,4-dimethoxyphenyl)boronic acid(SALTDATA: FREE) | | CAS: | 122775-35-3 | | MF: | C8H11BO4 | | MW: | 181.98 | | EINECS: | 679-694-8 | | Product Categories: | Substituted Boronic Acids;Alkoxy;blocks;BoronicAcids;Aryl;Organoborons;Boronic Acid series;Boronic Acid;B (Classes of Boron Compounds);Boronic Acids;Boronic Acids;Boronic Acids and Derivatives | | Mol File: | 122775-35-3.mol |  |
| | 3,4-Dimethoxyphenylboronic acid Chemical Properties |
| Melting point | 245-250 °C (lit.) | | Boiling point | 336.7±52.0 °C(Predicted) | | density | 1.19±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 8.48±0.10(Predicted) | | form | Powder and Granules | | color | White to light beige | | Water Solubility | 25 g/L | | BRN | 5334877 | | InChI | InChI=1S/C8H11BO4/c1-12-7-4-3-6(9(10)11)5-8(7)13-2/h3-5,10-11H,1-2H3 | | InChIKey | RCVDPBFUMYUKPB-UHFFFAOYSA-N | | SMILES | B(C1=CC=C(OC)C(OC)=C1)(O)O | | CAS DataBase Reference | 122775-35-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26-36/37 | | WGK Germany | 3 | | Hazard Note | Irritant/Keep Cold | | HazardClass | IRRITANT | | HS Code | 29319090 | | Storage Class | 11 - Combustible Solids |
| | 3,4-Dimethoxyphenylboronic acid Usage And Synthesis |
| Chemical Properties | white to light beige powder and granules | | Uses | 3,4-Dimethoxyphenylboronic acid can be used:
- As a substrate in the cross-coupling reaction with 5,7-dichloropyrido[4,3-d]pyrimidine catalyzed by palladium.
- As a starting material for the synthesis of buflavine 1, a natural alkaloid.
- In one of the key synthetic steps for the preparation of lipidated malarial glycosylphosphatidylinositols (GPI) disaccharide.
- To prepare 3,3″,4,4″-tetramethoxy-1,1′:4′,1″-terphenyl by reacting with 1,4-dibromobenzene using Pd catalyst.
| | Uses | suzuki reaction | | Synthesis | GENERAL PROCEDURE: 3,4-Dimethoxyaniline (0.5 mmol, 1.0 eq.) was dissolved in methanol (1.0 mL), hydrochloric acid (0.5 mL, 1.5 mmol, 3.0 eq.) was slowly added, followed by water (0.5 mL). The reaction mixture was stirred for 2 min, then sodium nitrite solution (0.25 mL, prepared by dissolving 35 mg NaNO2 in 0.25 mL of water) was added. The reaction mixture was stirred at 0-5 °C for 30 min, followed by the addition of methanol (1.0 mL) and hydrochloric acid (135 mg, 1.5 mmol, 3.0 equiv). Stirring was continued for 60 min. Upon completion of the reaction, it was diluted with water (10 mL) and extracted with dichloromethane (50 mL, 3 times). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 3,4-dimethoxyphenylboronic acid. | | References | [1] Synlett, 2014, vol. 25, # 11, p. 1577 - 1584 |
| | 3,4-Dimethoxyphenylboronic acid Preparation Products And Raw materials |
|