H-151
中文名称 | H-151 |
---|---|
中文同义词 | 1-(4-乙基苯基)-3-(1H-吲哚-3-基)脲;化合物H-151;H 151,STING拮抗剂;1-(4-乙基苯基)-3-(3-吲哚基)脲 |
英文名称 | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea |
英文同义词 | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea;H151;H-151;H-151;H-151;STING ANTAGONIST;STING antagonist;N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea;H-151;H 151 NEW;Urea, N-(4-ethylphenyl)-N'-1H-indol-3-yl-;STING inhibitor |
CAS号 | 941987-60-6 |
分子式 | C17H17N3O |
分子量 | 279.34 |
EINECS号 | |
相关类别 | |
Mol文件 | 941987-60-6.mol |
结构式 |
H-151 性质
沸点 | 399.9±25.0 °C(Predicted) |
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密度 | 1.298±0.06 g/cm3(Predicted) |
储存条件 | Sealed in dry,Room Temperature |
溶解度 | 溶于 DMSO (25 mg/ml) |
形态 | 固体 |
酸度系数(pKa) | 14.96±0.70(Predicted) |
颜色 | 米白色 |
稳定性 | 可在-20°C下的DMSO中的溶液储存长达3个月。 |
Target | Value |
STING
() |
H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells.
H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells.
H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation.
H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice.
H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in
Trex1
−/−
mice that expressed a bioluminescent IFNβ reporter.
H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-112693 | H-151 H-151 | 941987-60-6 | 5 mg | 800元 |
2024/08/19 | S6652 | H-151 | 941987-60-6 | 10mM (1mL in DMSO) | 958.23元 |