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DL-Menthol

Menthol is a cyclic terpene alcohol flavors and fragrances with its appearance exhibiting colorless needle or shuttle columnar crystal or white crystalline powder. It has special aroma of mint with its taste being hot at first but then being cool later. It exhibit neutralizing reaction in the ethanol solution, being extremely easily soluble in ethanol, chloroform, petroleum ether, ether, liquid paraffin or volatile oil and being very slightly soluble in water.
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Products Intro: Product Name:DL-Menthol
CAS:89-78-1
Purity:98% Min. Package:100g;1kg;5kg,10kg,25kg,50kg
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CAS:89-78-1
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CAS:89-78-1
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Purity:99% Package:500G;1KG;5KG;25KG
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Products Intro: Product Name:DL-Menthol
CAS:89-78-1

Lastest Price from DL-Menthol manufacturers

  • DL-MENTHOL
  • US $10.00 / KG
  • 2019-08-07
  • CAS:89-78-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10 mt
  • Menthol 89-78-1
  • US $14.50 / mg
  • 2019-07-11
  • CAS:89-78-1
  • Min. Order: 20mg
  • Purity: ≥98%
  • Supply Ability: 1000.00 kgs
  • DL-Menthol
  • US $1.00 / kg
  • 2019-07-06
  • CAS:89-78-1
  • Min. Order: 1 g
  • Purity: 99%
  • Supply Ability: 100KG
DL-Menthol Basic information
Flavors and fragrances First aid of poisoning Detection method Chemical properties Uses
Product Name:DL-Menthol
Synonyms:(1α,2β,5α)-5-methyl-2-(1-methylethyl)cyclohexanol;2-(1-methylethyl)-5-methyl-cyclohexanol;2-isopropyl-5-methyl-cyclohexano;5alpha-Methyl-2beta-(1alpha-methylethyl)cyclohexanol;component of Dermoplast;component of Robitussin cough drops;component of Theragesic;Cyclohexanol, 2-isopropyl-5-methyl-
CAS:89-78-1
MF:C10H20O
MW:156.27
EINECS:201-939-0
Product Categories:Terpenes and Terpenoids (Isoprenoids);Alcohols;Building Blocks;C9 to C10;Chemical Synthesis;Nutrition Research;Ocimum basilicum (Basil);Organic Building Blocks;Oxygen Compounds;Phytochemicals by Chemical Classification;Phytochemicals by Plant (Food/Spice/Herb);Sambucus nigra (Elderberry);API Intermediate;chemical reagent;-;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Flavor & essential oil;Inhibitors;Monoterpenoids
Mol File:89-78-1.mol
DL-Menthol Structure
DL-Menthol Chemical Properties
Melting point 34-36 °C(lit.)
Boiling point 216 °C(lit.)
alpha -2 º (c=10, EtOH)
density 0.89 g/mL at 25 °C(lit.)
vapor pressure 0.8 mm Hg ( 20 °C)
refractive index 1.4615
FEMA 2665 | MENTHOL RACEMIC
Fp 200 °F
storage temp. Store below +30°C.
solubility 456mg/l
form Crystalline Solid
color Colorless to white
Water Solubility insoluble
Merck 14,5837
JECFA Number427
BRN 3194263
CAS DataBase Reference89-78-1(CAS DataBase Reference)
NIST Chemistry ReferenceDL-Menthol(89-78-1)
EPA Substance Registry SystemCyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-rel-(89-78-1)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 37/38-41-36/37/38
Safety Statements 36/37/39-24/25-36-26-39
RIDADR UN 1888 6.1/PG 3
WGK Germany 2
RTECS OT0350000
Autoignition Temperature405 °C
TSCA Yes
HS Code 29061100
Hazardous Substances Data89-78-1(Hazardous Substances Data)
ToxicityLD50 orally in rats: 3180 mg/kg (Jenner)
MSDS Information
ProviderLanguage
p-Menthan-3-ol English
DL-Menthol Usage And Synthesis
Flavors and fragrancesMenthol is a cyclic terpene alcohol flavors and fragrances with its appearance exhibiting colorless needle or shuttle columnar crystal or white crystalline powder. It has special aroma of mint with its taste being hot at first but then being cool later. It exhibit neutralizing reaction in the ethanol solution, being extremely easily soluble in ethanol, chloroform, petroleum ether, ether, liquid paraffin or volatile oil and being very slightly soluble in water.
Its molecular structure contains three asymmetric carbon atoms, so it has four stereoisomers with their aroma intensity and type and cool feeling being different. There are two common types: natural menthol and synthetic menthol. Natural menthol is a kind of saturated ring alcohol obtained through the freezing & crystallization, separation and refinement of peppermint oil with the optical rotation being L; synthetic menthol is made from taking lemon eucalyptus oil as raw material.
Its main component can be manufactured from the ring closing reaction of citronellal to obtain isopulegol, followed by hydrogenation, or through the synthesis of thymol from m-cresol with catalytic hydrogenation resulting in four menthol mixture of isomers with the precise vacuum distillation obtaining defined synthetic menthol, being racemate with no optical rotation. It has bactericidal and anti-corrosion effect and can be used as the fragrance of toothpaste, perfume, beverages and confectionery. In the medicine, it can be used for making cool oil, painkillers, mouthwash, and so on.
The main applications are as follows:
1. Menthol can act on the skin sensory nerve end, making the skin surface to produce cool feeling, achieving the purpose of itching prevention. Topical administration to the affected area can be used for the treatment of urticaria, prurigo, prickly heat, rash, neurodermatitis and skin pruritus and so on.
2. It can be used for the treatment of headache, nasal congestion and sore throat. This product has pleasant aroma and has curing effect on treating cold and wind heat. It has effects of refreshing the mind and clearing the throat.
First aid of poisoningTopical application of menthol have effects of promoting blood circulation and anti-inflammatory, anti-itching and can be applied to anti-inflammatory, antipruritic, analgesic and reducing swelling and so on.
【Diagnosis】
1. Oral administration of large amount of menthol or inhaling of large amount of menthol gas can lead to gastrointestinal symptoms such as nausea, vomiting and abdominal pain as well as nervous system symptoms such as excitement, tremor, dizziness, vertigo, hand and foot numbness, swing gait, lethargy, breathing changes, facial flushing, reduced blood pressure, muscle rigidity or relaxation, occasional being not able to speak; children, after taking a large dose, can have coma. But it can be generally restored within a few hours.
2. Patients allergic to this chemical can get with eczema with unbearable itching feeling.
3. Small infants, sometimes due to nasal mint liquid or ointment, can get glottis spasm, accompanied with bruising and suffocation as well as secretion of large amounts of mucus. In severe cases, it may be occurred of respiratory and cardiac arrest.
【Treatment principles】
1. Gastric lavage; conduct catharsis with salt cathartic. Avoid using fats and oils.
2. Apply intravenous rehydration to promote excretion.
3. In cases of allergic symptoms, we should treat with antihistamines such as diphenhydramine, chlorpheniramine, etc.; if necessary, we can apply hydrocortisone or dexamethasone intravenously.
Detection method(1) Chemical qualitative method
① take 1 g of this product, add 20 mL of sulfuric acid to dissolve it, so the reaction mixture becomes orange-red. After 24h, there will be colorless oil layer of non-menthol aroma precipitated out (the distinction from thymol).
② take 50 mg of this product, add 1mL of ice acetic acid to dissolve it; Addition of 6 drops of sulfuric acid and 1 drop of nitric acid to the cold mixture will lead to only slightly yellow color (the difference from thymol).
(2) thin-layer chromatography: take appropriate amount of menthol and dissolve in anhydrous ethanol, make a solution containing 6 mg menthol per mL for spotting. TLC: silica gel G manual plating, make it dry; have it subjected to activation in 105 °C for 1 hour and standby. Developing agent A: n-hexane-ethyl acetate-benzene (43: 4.5: 4); Developing agent B: petroleum-ether-ethyl acetate-chloroform (25: 2.5: 5.5). Coloration reagent: 5% vanillin ethanol solution-concentrated sulfuric acid (100: 6). Coloration: heating at 105 ℃ for 6~10min, exhibiting a circular blue spots.
(3) Determination of physical constants: melting point: 42 ℃~44 °C. Specific rotation: take this product for accurately weighing; add ethanol to make a solution of 0.1 g/mL. Measure according to the method, the specific rotation is-49 ° ~-50 °.
(4) non-volatile matter: take 2 g of this product and place it in the pre-weighed evaporating dish; have it heated in the water bath so it is slowly evaporated; dried at 105 ℃ to constant weight with the leftover residue not exceeding 1mg.
Chemical propertiesL-form appears as colorless needle crystal. The melting point is 42-43 °C; the boiling point is 216 °C, the specific rotation:-51 °-45 °; the flash point: 93 °C; the relative density: 0.8810; it is soluble in ethanol and is miscible with oil. It has cool, fresh, pleasant mint characteristic aroma with sweet spiky gas. It gives people a cold feeling with aroma penetrating through the hair, but not lasting. The taste is also fresh sweet cool taste.
UsesIt is mainly used in medicine, toothpaste, toothpaste and mouthwash with its cool taste being able to enhance the smell of peppermint oil, having effect of refreshing the brain as well as disinfection effects. It can also be used as spices to be applied to the colognes. Application of appropriate amount of low-grade soap and detergent fragrance such as roses, geraniol, lavender and fragrant has effects of enhancing the tone and aroma. It can also be applied to food flavors and flavor for wine and tobacco.
In medicine, it can be applied to the cooling oil, painkillers, etc., it can also be used for making toothpaste, toothpowder, candy, beverages, spices and so on. How to use: it can be used for formulating the food flavor in the food flavor plant; or also be directly added or dissolved in alcohol to be added to the food flavoring. Storage requirements: placed in a cool place, sealed for storage. Avoid wind and rain.
DescriptionMenthol has a mint-like odor and a fresh, cooling taste. It may be prepared by hydrogenation of thymol.
Chemical PropertiesMenthol has a peppermint-like odor and exerts a cooling sensation when applied to skin and mucosal surfaces. Menthol is a monocyclic terpene alcohol with three asymmetric carbon atoms in its cyclohexane ring resulting in (–) and (+) menthol, neomen thol, isomenthol and neoisomenthol. (–)-Menthol is the isomer that occurs most widely in nature and is the one commonly identified as menthol.
Chemical Propertiescolorless to white crystalline solid
OccurrenceReported found in peppermint and other mint oils (e.g., M. arvensis), lemon peel oil, cranberry, pineapple, cab bage, thymus, egg, rum, cocoa, tea, honey, avocado, coriander, mango, rice, litchi, dill herb, calamus, juniper berries, fennel, buchu oil, clam and Roman chamomile oil, Mentha species.
UsesA chemical which triggers cold-sensitive TRPM8 receptors in the skin neurons in vitro.
UsesIn liqueurs, confectionery, perfumery, cigarettes, cough drops, and nasal inhalers.
PreparationBy hydrogenation of thymol.
Aroma threshold valuesDetection: 950 ppb to 2.5 ppm; aroma characteristics at 1.0%: cooling menthol with a penetrating minty eucalyptus note.
Taste threshold valuesTaste characteristics at 25 ppm: cooling, camphoreous, minty with a clean eucalyptus note.
General DescriptionWhite crystalline solid with a peppermint odor and taste.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileDL-Menthol is incompatible with butyl chloral hydrate, camphor, phenol, chloral hydrate, Exalgine, betanaphthol, resorcinol or thymol in triturations; potassium permanganate, chromium trioxide and pyrogallol. DL-Menthol is also incompatible with strong oxidizers.
HazardIrritant to mucous membranes on inhalation.
Fire HazardDL-Menthol is combustible.
Safety ProfilePoison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. A severe eye irritant. Incompatible with phenol, p-naphthol, resorcinol or thymol in trituration, potassium permanganate, chromium trioxide, pyrogallol. Combustible liquid. \When heated to decomposition it emits acrid smoke and irritating fumes.
DL-Menthol Preparation Products And Raw materials
Preparation ProductsL-Menthol-->3,7-DIMETHYL-7-OCTEN-1-OL-->CITRONELLYL FORMATE
Raw materialsPeppermint oil
Tag:DL-Menthol(89-78-1) Related Product Information
G-STROPHANTHIN DIGITOXIGENIN LANATOSIDE B UZARIN DL-Menthol Chloromethyl isopropyl carbonate 2-Methyl-2-propenoic acid cyclohexyl ester (+)-MENTHOL 1-Ethynyl-1-cyclohexanol 1-Methylcyclohexanol Cyclohexanol (+)-ISOMENTHOL ISOPULEGOL, TECH. 2-Methylcyclohexanol L-Menthol DL-Menthol, racemic,DL-MENTHOL USP (RACEMIC) SYNTHETIC N,N-Dimethylcyclohexylamine METHYLCYCLOHEXANOL