洛索立宾
中文名称 | 洛索立宾 |
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中文同义词 | 洛索立宾;7-烯丙基-8-氧代鸟苷;7-烯丙基-7,8-二氢-8-羰基鸟苷;7-烯丙基-7,8-二氢-8-氧代鸟苷;7-烯丙基-2-氨基-9-((2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基)-1H-嘌呤-6,8(7H,9H)-二酮 |
英文名称 | Loxoribine |
英文同义词 | 7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95;Loxoribine;7-Allyl-2-amino-9-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7,9-dihydro-1H-purine-6,8-dione;7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine;RWJ 21757;Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)-;7-Allyl-7,8-dihydro-8-oxoguanosine 95%;7,8-Dihydro-8-oxo-7-allyl-guanosine |
CAS号 | 121288-39-9 |
分子式 | C13H17N5O6 |
分子量 | 339.3 |
EINECS号 | |
相关类别 | Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;Nucleosides;Oligonucleotide Synthesis;Specialty Synthesis |
Mol文件 | 121288-39-9.mol |
结构式 |
洛索立宾 性质
熔点 | 227-230 °C(lit.) |
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密度 | 1.92±0.1 g/cm3(Predicted) |
储存条件 | Desiccate at +4°C |
溶解度 | 溶于 DMSO(高达 25 mg/ml)。 |
形态 | 白色至类白色固体。 |
酸度系数(pKa) | 10.29±0.20(Predicted) |
颜色 | 白色 |
旋光性 (optical activity) | [α]21/D 32°, c = 1 in H2O |
稳定性 | DMSO中的溶液可在-20°下稳定储存3个月。 |
TLR7
Loxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability.
Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7.
loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway.
Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo.
Animal Model: | 8-12 weeks male CBA/J mice |
Dosage: | 2 mg |
Administration: | Subcutaneous or intravenous injection |
Result: | activates murine natural killer (NK) cells in vivo. |
安全信息
WGK Germany | 3 |
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海关编码 | 29349990 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-108472 | 洛索立宾 Loxoribine | 121288-39-9 | 5mg | 400元 |
2024/08/19 | HY-108472 | 洛索立宾 Loxoribine | 121288-39-9 | 10mM * 1mLin DMSO | 440元 |