阿替美唑
| 中文名称 | 阿替美唑 |
|---|---|
| 中文同义词 | 阿替美唑;阿替美咗;4-(2-乙基-2-茚满)咪唑;阿替美唑/阿替美咗;化合物ATIPAMEZOLE;5-(2-乙基-2,3-二氢-1H-茚-2-基)-1H-咪唑;PERFEMIKER]阿替美唑,98% |
| 英文名称 | Atipamezole |
| 英文同义词 | atipamezole;4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole;4-(2-Ethyl-2-indanyl)imidazole;MPV-1248;5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole;1H-Imidazole, 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-;5-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole |
| CAS号 | 104054-27-5 |
| 分子式 | C14H16N2 |
| 分子量 | 212.29 |
| EINECS号 | 1806241-263-5 |
| 相关类别 | 信号转导通路激酶抑制剂;原料药;合成;API |
| Mol文件 | 104054-27-5.mol |
| 结构式 |  |
阿替美唑 性质
| 熔点 | 126-129oC |
|---|---|
| 沸点 | 367.1±11.0 °C(Predicted) |
| 密度 | 1.115±0.06 g/cm3(Predicted) |
| 储存条件 | room temp |
| 溶解度 | 二甲基亚砜：≥30mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 14.05±0.10(Predicted) |
| 颜色 | 白色至棕色 |
| InChI | InChI=1S/C14H16N2/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14/h3-6,9-10H,2,7-8H2,1H3,(H,15,16) |
| InChIKey | HSWPZIDYAHLZDD-UHFFFAOYSA-N |
| SMILES | C1NC(C2(CC)CC3=C(C2)C=CC=C3)=CN=1 |
| CAS 数据库 | 104054-27-5(CAS DataBase Reference) |
| Target | Value |
|
α2 adrenergic receptor
() |
The affinity of atipamezole for α 2 -adrenoceptors and its α 2 /α 1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α 2 -adrenoceptors. It has negligible affinity for 5-HT 1 , 5-HT2 and I2 bindings sites.
Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory.
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-12380A | Atipamezole | 5 mg | 487元 | |
| 2024/01/25 | HY-12380A | 阿替美唑 Atipamezole | 104054-27-5 | 10mg | 780元 |