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| | 2-Methoxy-3-(trifluoromethyl)pyridine Basic information | | storage Uses |
| | 2-Methoxy-3-(trifluoromethyl)pyridine Chemical Properties |
| Boiling point | 44 °C | | density | 1.297 g/mL at 25 °C | | refractive index | n20/D 1.441 | | Fp | 118 °F | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | soluble in Methanol | | form | clear liquid | | pka | 0.97±0.10(Predicted) | | color | Colorless to Almost colorless | | InChI | InChI=1S/C7H6F3NO/c1-12-6-5(7(8,9)10)3-2-4-11-6/h2-4H,1H3 | | InChIKey | SSAZZVQVJJXPMB-UHFFFAOYSA-N | | SMILES | C1(OC)=NC=CC=C1C(F)(F)F | | CAS DataBase Reference | 121643-44-5(CAS DataBase Reference) |
| | 2-Methoxy-3-(trifluoromethyl)pyridine Usage And Synthesis |
| storage | 2-Methoxy-3-(trifluoromethyl)pyridine store at room temperature. | | Uses | 2-Methoxy-3-(trifluoromethyl)pyridine belongs to pyridine derivatives and can be used as pharmaceutical intermediates. | | Synthesis | 2-Chloro-3-trifluoromethylpyridine (3 g, 16.53 mmol) was dissolved in 30 mL of a methanol solution of sodium methanolate (5.4 M). The reaction mixture was stirred at room temperature for 48 hours. After completion of the reaction, the mixture was cooled in an ice bath and extracted three times with dichloromethane (DCM). The organic phases were combined, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure to afford 2-methoxy-3-trifluoromethylpyridine as a colorless liquid (2.7 g, 89% yield). The product was characterized by 1H-NMR (400 MHz, DMSO-d6, 298 K): δ 3.98 (s, 3H), 7.2 (dd, 1H), 8.11 (d, 1H), 8.45 (d, 1H). Mass Spectrometry (MS): m/z 178.1 [M+1]+, retention time (Rt) = 1.29 min. | | References | [1] Patent: WO2013/57711, 2013, A1. Location in patent: Page/Page column 45-46
[2] Patent: WO2013/88404, 2013, A1. Location in patent: Page/Page column 92
[3] Patent: US2015/342951, 2015, A1. Location in patent: Paragraph 0841-0842 |
| | 2-Methoxy-3-(trifluoromethyl)pyridine Preparation Products And Raw materials |
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