| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:PETCM;α-(TrichloroMethyl)-4-pyridineethanol
CAS:10129-56-3
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Basic information |
| Product Name: | ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL | | Synonyms: | PETCM;APOPTOSIS ACTIVATOR I;ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL;1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE;1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL;a-(Trichloromethyl)-4-pyridineethanol;α-(Trichloromethyl)-4-pyridineethanol;α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane | | CAS: | 10129-56-3 | | MF: | C8H8Cl3NO | | MW: | 240.51 | | EINECS: | | | Product Categories: | Caspase/Related products. | | Mol File: | 10129-56-3.mol |  |
| | ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Chemical Properties |
| Boiling point | 342.2±37.0 °C(Predicted) | | density | 1.465±0.06 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | DMSO: 22 mg/mL, soluble | | form | solid | | pka | 12.07±0.20(Predicted) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 |
| | ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Usage And Synthesis |
| Uses | PETCM is a caspace-3 activator in cell extracts. | | Definition | ChEBI: 1,1,1-trichloro-3-pyridin-4-yl-2-propanol is a member of pyridines. | | Biological Activity | petcm is an activator of caspase-3 [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.in hela s-100 cell cytosol, petcm activated caspase-3 in a dose-dependent way and induced apoptosome formation. petcm (0.2 mm) caused apaf-1 shifted to a size of ~1 million daltons, which indicating apoptosome formation. also, petcm function required datp. the activation effect of petcm on caspase-3 was independent of phap proteins. when inhibited the activation activity of the phap proteins, petcm reversed the suppression. when added to q30 (apaf-1/procaspase-9) plus cytochrome c and 10 μm datp, recombinant phapi activated caspase-3. the activity was inhibited by recombinant prot. while, petcm reversed the inhibitory effect of prot. phapi didn’t affect apoptosome formation and activated caspase-9 and apaf-1, which were associated with apoptosome. prot efficiently blocked formation of apoptosome and petcm relieved this effect [1]. | | storage | Room temperature | | references | [1]. jiang x, kim he, shu h, et al. distinctive roles of phap proteins and prothymosin-alpha in a death regulatory pathway. science, 2003, 299(5604): 223-226. |
| | ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Preparation Products And Raw materials |
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