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| Product Name: | PPT | | Synonyms: | 4,4',4''-(4-PROPYL-[1H]-PYRAZOLE-1,3,5-TRIYL)TRISPHENOL;1,3,5-TRIS(4-HYDROXYPHENYL)-4-PROPYL-1H-PYRAZOLE;PPT;Propylpyrazole Triol;-triyl)trisphenol;Phenol, 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris-;4,4',4''-(4-Propyl-1H-pyrazole-1,3,5-triyl)triphenol;1,3,5-tris(4-hydroxyphenyl)-4-propylpyrazole | | CAS: | 263717-53-9 | | MF: | C24H22N2O3 | | MW: | 386.44 | | EINECS: | | | Product Categories: | Intracellular receptor;Nuclear Receptors | | Mol File: | 263717-53-9.mol |  |
| Melting point | 230 °C (decomp) | | Boiling point | 630.0±55.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 20 mg/mL, soluble | | form | solid | | pka | 8.80±0.15(Predicted) | | color | off-white |
| Uses | PPT is a potent and specific ERα agonist. | | Definition | ChEBI: 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol is a pyrazole that is 1H-pyrazole bearing three 4-hydroxyphenyl substituents at positions 1, 3 and 5 as well as a propyl substituent at position 4. Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERalpha over ERbeta. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. It has a role as an estrogen receptor agonist. It is a member of pyrazoles and a member of phenols. | | General Description | Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily. It is also known as ESR1 (estrogen receptor). It is located on human chromosome 6q25.1.
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole is also termed as PPT. ERα is found in the nuclear and extranuclear sites in principal and inhibitory neurons. | | Biological Activity | Potent, subtype-selective estrogen receptor agonist (EC 50 ~ 200 pM); displays 410-fold selectivity for ER α over ER β . Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo . | | Biochem/physiol Actions | Estrogen receptor α (ERα) is involved in immune and inflammatory responses. Aberrations in ESR1 results in Mayer-Rokitansky-Kuster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina. | | storage | +4°C |
| | PPT Preparation Products And Raw materials |
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