- R-1479
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- $112.00 / 1mg
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2025-12-10
- CAS:478182-28-4
- Min. Order:
- Purity: 99.95%
- Supply Ability: 10g
- 4'-Azidocytidine
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- $7.00 / 1KG
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2019-09-02
- CAS: 478182-28-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: JD 553
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| | 4'-Azidocytidine Basic information |
| Product Name: | 4'-Azidocytidine | | Synonyms: | 4'-Azidocytidine;R-1479;4'-C-azidocytidine;4'-alpha-Azido-cytidine;Cytidine, 4'-C-azido-;R 1479;4'-AZIDOCYTIDINE;R1479;4’-alpha-Azido-cytidine, Balpiravir, R-1479;4’-α-Azido-cytidine | | CAS: | 478182-28-4 | | MF: | C9H12N6O5 | | MW: | 284.23 | | EINECS: | | | Product Categories: | | | Mol File: | 478182-28-4.mol |  |
| | 4'-Azidocytidine Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: ≥ 50 mg/mL (175.91 mM) | | form | Powder | | color | White to off-white |
| | 4'-Azidocytidine Usage And Synthesis |
| Uses | R-1479 (4'-Azidocytidine), a nucleoside analogue, is a specific inhibitor of RNA-dependent RNA polymerase (RdRp) of HCV. R-1479 inhibits HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM)[1][2][3]. R-1479 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | target | HCV | | References | [1] Klumpp K, et al. The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. J Biol Chem. 2006 Feb 17;281(7):3793-9. DOI:10.1074/jbc.M510195200
[2] Smith DB, et al. Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. Bioorg Med Chem Lett. 2007 May 1;17(9):2570-6. DOI:10.1016/j.bmcl.2007.02.004
[3] Nguyen NM, et al. A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. J Infect Dis. 2013 May 1;207(9):1442-1450. DOI:10.1093/infdis/jis470 |
| | 4'-Azidocytidine Preparation Products And Raw materials |
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