CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
生物活性体外研究体内研究 用途与合成方法 MSDS CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE价格(试剂级) 上下游产品信息
| 中文名称 | CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE |
|---|---|
| 中文同义词 | 半胱天冬酶-1 抑制剂 V;PASE-1 INHIBITOR V;化合物Z-ASP-CH2-DCB |
| 英文名称 | Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE |
| 英文同义词 | N-cbz-L-aspartic acid A-(2,6-dichloro-*benzoyloxy;N-CBZ-L-ASPARTIC ACID A-(2 6-DICHLORO- &;INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITOR III;N-CBZ-L-aspartic acid alpha-[(2,6-dichlorobenzoyloxy)....;Z-L-Asp α-([2,6-dichlorobenzoyloxy]methyl ketone);CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE;ICE INHIBITOR V;ICE INHIBITOR VI |
| CAS号 | 153088-73-4 |
| 分子式 | C20H17Cl2NO7 |
| 分子量 | 454.26 |
| EINECS号 | |
| 相关类别 | Pepetides;peptides;Caspase/Related Products |
| Mol文件 | 153088-73-4.mol |
| 结构式 |  |
CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE 性质
| 沸点 | 674.2±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.440±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 溶于 DMSO（高达 25 mg/ml）。 |
| 形态 | 白色至类白色粉末。 |
| 酸度系数(pKa) | 4.01±0.19(Predicted) |
| 颜色 | 白色 |
| 稳定性 | 自购买之日起 1 年内保持稳定。 DMSO 中的溶液可在 -20° 下保存长达 3 个月。 |
Z-Asp-CH2-DCB 是一种不可逆的广谱 caspase 抑制剂，Z-Asp-CH2-DCB 也能抑制具有 caspase 样活性的蛋白酶。Z-D-CH2-DCB 并以剂量依赖的方式阻断 PBMC 细胞中的金黄色葡萄球菌肠毒素 B (SEB) 刺激的 IL-1β、TNF-α、IL-6 和 IFN-γ 的产生，和降低 SEB-1 刺激的 T 细胞增殖。Z-Asp-CH2-DCB 可预防 SU5416 诱导的间隔细胞凋亡和肺气肿的发生。
Z-Asp-CH2-DCB (10-100 μM) blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng; 16 hours) PBMC in a dose-dependent manner. The production of the chemokines MCP-1, MIP-1α, and MIP-1β was also suppresses. The inhibitory effect of Z-Asp-CH2-DCB on TSST-1-activated PBMC is similar, reducing IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β to 10, 36, 25, 10, 11, 25, and 30%, respectively, of levels in untreated cells.
Z-Asp-CH2-DCB (10-100 μM; 48 hours) inhibits T-cell proliferation in PBMC stimulated with 200 ng of SEB/ml .
Cell Viability Assay
| Cell Line: | Human peripheral blood mononuclear cells |
| Concentration: | 10, 50, 100 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited T-cell proliferation in PBMC stimulated with SEB. |
Z-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks) prevents SU5416-induced septal cell apoptosis.
| Animal Model: | Male Sprague-Dawley rats (SU5416+ Z-Asp-CH2-DCB group) |
| Dosage: | 1 mg |
| Administration: | Intraperitoneal injection; every day for 3 weeks |
| Result: | The caspase 3-like activity in SU5416-treated rat lungs is significantly higher, whereas lungs from rats treated with SU5416+Z-Asp-CH2-DCB showed no increase in apoptotic activity. |
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-113953 | CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE Z-Asp-CH2-DCB | 153088-73-4 | 1mg | 500元 |
| 2024/04/30 | HY-113953 | CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE Z-Asp-CH2-DCB | 153088-73-4 | 5mg | 800元 |