| Company Name: |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. |
| Tel: |
+86-021-61551413 +8618813727289 |
| Email: |
contact@trustwe.com |
| Products Intro: |
Product Name:(3'S)-1',2',5,7-tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2'-oxo-Spiro[6H-
CAS:1374248-81-3
Purity:99% HPLC Package:5KG;1KG
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Atogepant (MK-8031) manufacturers
- Atogepant
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- $0.00 / 1g
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2024-03-12
- CAS:1374248-81-3
- Min. Order: 1g
- Purity: 98% HPLC
- Supply Ability: 1kg
Related articles - How is Atogepant synthesised?
- Atogepant was synthesised from the late-stage amide coupling of two highly complex fragments (Carboxylic Acid Fragment and Spi....
- Jan 15，2024
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| | Atogepant (MK-8031) Basic information |
| Product Name: | Atogepant (MK-8031) | | Synonyms: | MK-8031;Spiro[6H-cyclopenta[b]pyridine-6,3'-[3H]pyrrolo[2,3-b]pyridine]-3-carboxamide, 1',2',5,7-tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2'-oxo-, (3'S)-;(S)—N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2’-oxo-1’,2’,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3’-pyrrolo[2,3-b]pyridine]-3-carboxamide;(S)—N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamid;MK8031. Atogepant;Atogepant API;(S)-1'-(tert-butyl)-N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide;(3'S)-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxamide | | CAS: | 1374248-81-3 | | MF: | C29H23F6N5O3 | | MW: | 603.52 | | EINECS: | | | Product Categories: | | | Mol File: | 1374248-81-3.mol |  |
| | Atogepant (MK-8031) Chemical Properties |
| Boiling point | 693.9±55.0 °C(Predicted) | | density | 1.54±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 11.08±0.20(Predicted) |
| | Atogepant (MK-8031) Usage And Synthesis |
| Uses | Atogepant (MK-8031) is an orally active and selective calcitonin gene–related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine. | | Definition | ChEBI: Atogepant is a secondary carboxamide resulting from the formal condensation of the carboxy group of (3'S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid with the amino group of (3S,5S,6R)-3-amino-6-methyl-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-2-one. It is a selective oral, small-molecule antagonist of calcitonin gene-related peptide (CGRP) receptor that has been approved for the treatment of migraine. It has a role as a calcitonin gene-related peptide receptor antagonist. It is a secondary carboxamide, an azaspiro compound, an organic heterotetracyclic compound, a trifluorobenzene and a member of piperidones. | | Mechanism of action | Atogepant (MK-8031) is an antagonist of the calcitonin gene-related peptide receptor. It competes with CGRP for occupancy at these receptors, preventing the actions of CGRP and its ability to induce and perpetuate migraine headache pain. |
| | Atogepant (MK-8031) Preparation Products And Raw materials |
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