- 4-Nitrophthalonitrile
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- $76.74
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2026-09-21
- CAS:31643-49-9
- Min. Order: 25Kg/Drum
- Purity: 99.50%HPLC
- Supply Ability: 3tons/month
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| | 4-Nitrophthalonitrile Basic information |
| | 4-Nitrophthalonitrile Chemical Properties |
| Melting point | 142-144 °C(lit.) | | Boiling point | 303.75°C (rough estimate) | | density | 1.4553 (rough estimate) | | refractive index | 1.6500 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | form | Crystalline Powder, Crystals and/or Chunks | | color | Light yellow, light greenish or light gray to beige | | Water Solubility | Sparingly soluble in water.(0.26 g/L) (25°C), | | BRN | 1877554 | | Major Application | diagnostic assay manufacturing
hematology
histology | | InChI | InChI=1S/C8H3N3O2/c9-4-6-1-2-8(11(12)13)3-7(6)5-10/h1-3H | | InChIKey | NTZMSBAAHBICLE-UHFFFAOYSA-N | | SMILES | C1(C#N)=CC=C([N+]([O-])=O)C=C1C#N | | CAS DataBase Reference | 31643-49-9(CAS DataBase Reference) | | EPA Substance Registry System | 1,2-Benzenedicarbonitrile, 4-nitro- (31643-49-9) |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38-20/21/22 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | TI8576000 | | TSCA | TSCA listed | | HS Code | 29269090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | | Toxicity | mouse,LD50,oral,500mg/kg (500mg/kg),SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTIONBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION,Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(9), Pg. 92, 1987. |
| | 4-Nitrophthalonitrile Usage And Synthesis |
| Chemical Properties | light yellow, light greenish or light grey to | | Uses | 4-Nitrophthalonitrile is a useful chemical in organic synthesis. Dyes and metabolites. | | Preparation | Synthesis of 4-Nitrophthalonitrile: SOCl2 (83.5 mL. 1.144 mol) was added dropwise under nitrogen purge to dry DMF (200 mL) which had been cooled to 0-5 °C. The solution was allowed to stir for 15 min at 0-5 °C. The 4-nitrophthalamide (60.1 g, 0.286 mol) was then added and the solution was allowed to slowly warm to room temperature and react for 18 h under nitrogen purge. The solution was then slowly added to ice water to crystallize and precipitate the product. The 4-nitrophthalonitrile was collected using vacuum filtration, washed with ice cold water, and allowed to air dry overnight; yield: 45.2 g (92%); m.p.: 141 °C (det. by DSC)
1 H NMR((CD3)2SO): 8.41 (dd, 1H), 8.67 (dd, 1H), 9.03 (dd, 1H) FTIR: 3091 (m, aromatic C-H stretch), 2242 (d, CN stretch), 1534 (s, asymmetric N=O stretch), 1349 (s, symmetric N=O stretch), 853 (s, C-N stretch) | | Synthesis | 4-Nitrophthalonitrile synthesized from phthalimide in three steps. The reaction time of ruthenium chloride and HZSM-5 catalysts was very shorter than ammonium molybdate and Hβ catalysts. The yield while we used ruthenium chloride and HZSM-5 catalysts were very higher than another.
In a three necked flask, 70 mL of dry dimethylformamide (DMF) was cooled to 0 °C under a stream of nitrogen and 7.3 mL of thionyl chloride was added so that the internal temperature did not go beyond 5 °C. After addition, nitrogen flow was ceased and a calcium chloride tube was added to the top of flask. Meanwhile, the color of the medium was observed to be yellow. Then, 10 g (0.048 mol) of 4- nitrophthalamide was slowly added so that the internal temperature did not go beyond 5 °C. The mixture was stirred over ice bath for 1 hour. The mixture was stirred at room temperature for 2 hours and then poured over 500 g of ice-water. The precipitate was filtered and washed successively with water, 250 mL 5% sodium hydrogencarbonate solution, and water again and dried in a vacuum oven at 110-120 °C. Molecular formula: C8H3N3O2. Yield: 7.4 g (90%). Mp: 141 °C. | | References | [1] Acta Chemica Scandinavica, 1999, vol. 53, # 9, p. 714 - 720
[2] Materials Research Bulletin, 2016, vol. 75, p. 144 - 154
[3] Heterocycles, 1984, vol. 22, # 9, p. 2047 - 2052
[4] Patent: EP413415, 1991, A1
[5] Russian Chemical Bulletin, 2003, vol. 52, # 1, p. 150 - 153 |
| | 4-Nitrophthalonitrile Preparation Products And Raw materials |
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