盐酸胡芦巴碱
中文名称 | 盐酸胡芦巴碱 |
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中文同义词 | N-甲基烟酸内盐盐酸盐;盐酸葫芦巴碱;胡卢巴碱盐酸盐;盐酸葫芦巴碱\葫芦巴碱盐酸盐、N-甲基烟酸内盐盐酸盐;葫芦巴碱盐酸盐(标准品);胡芦巴碱盐酸盐;盐酸胡芦巴碱;葫芦巴碱盐酸盐 |
英文名称 | Trigonelline hydrochloride |
英文同义词 | 1-METHYLPYRIDINIUM-3-CARBOXYLATE HYDROCHLORIDE;N-METHYLNICOTINIC ACID BETAINE HYDROCHLORIDE;TRIGONELLIN HYDROCHLORIDE;TRIGONELLINE HYDROCHLORIDE;TRIGONELLINE HCL;TIMTEC-BB SBB000182;3-carboxy-1-methylpyridinium chloride;EINECS 228-119-5 |
CAS号 | 6138-41-6 |
分子式 | C7H8ClNO2 |
分子量 | 173.6 |
EINECS号 | 228-119-5 |
植物来源 | 葫芦巴 |
相关类别 | 吡啶;小分子抑制剂;植物提取物;对照品;植提标准品;中药对照品;标准品;小分子抑制剂,天然产物;标准品 -中药标准品;Alkaloids;Biochemistry;Pyridine Alkaloids;Pyridinium Compounds;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;标准品,对照品;食品原料 |
Mol文件 | 6138-41-6.mol |
结构式 |
盐酸胡芦巴碱 性质
熔点 | ~260 °C (dec.) |
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储存条件 | Inert atmosphere,Room Temperature |
溶解度 | 少许溶于甲醇、可溶于水 |
形态 | 固体 |
颜色 | 白色至类白色 |
Merck | 14,9694 |
BRN | 3734169 |
稳定性 | 吸湿性 |
CAS 数据库 | 6138-41-6(CAS DataBase Reference) |
It is found that Trigonelline chloride (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline chloride attenuates H 2 O 2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline chloride regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H 2 O 2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirm that Trigonelline chloride significantly reduces the H 2 O 2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline chloride concentration against H 2 O 2 can induce the necrosis and apoptosis along with H 2 O 2 .
Trigonelline chloride decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline chloride significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline chloride differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.
安全信息
危险品标志 | Xi |
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危险类别码 | 36/37/38 |
安全说明 | 22-24/25-36-26 |
WGK Germany | 3 |
海关编码 | 29333990 |
提供商 | 语言 |
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英文
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